XRCC4 抗体
(X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4))
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008].
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Latest Publications for our XRCC4 抗体
: "Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability." in: Journal of cell science, Vol. 131, Issue 12, (2018) (PubMed).: "Quantitative proteomic analysis revealed changes in protein synthesis and mitochondrial functions after acute DNA damage in mouse neural stem cells." in: Neuroscience letters, Vol. 653, pp. 355-361, (2018) (PubMed).
: "Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes." in: Nature communications, Vol. 7, pp. 13049, (2018) (PubMed).
: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).
: "Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining." in: Nucleic acids research, Vol. 45, Issue 18, pp. 10583-10594, (2017) (PubMed).
: "A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage." in: Genes & development, Vol. 29, Issue 11, pp. 1151-63, (2015) (PubMed).
: "Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 20, pp. E2575-84, (2015) (PubMed).
: "A stress-induced cellular aging model with postnatal neural stem cells." in: Cell death & disease, Vol. 5, pp. e1116, (2014) (PubMed).
: "A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination." in: The Journal of experimental medicine, Vol. 210, Issue 12, pp. 2503-13, (2013) (PubMed).
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
Aliases for XRCC4 抗体
X-ray repair cross complementing 4 (XRCC4) 抗体X-ray repair complementing defective repair in Chinese hamster cells 4 (xrcc4) 抗体
X-ray repair complementing defective repair in Chinese hamster cells 4 L homeolog (xrcc4.L) 抗体
DNA ligase IV-binding protein (XRCC4) 抗体
X-ray repair complementing defective repair in Chinese hamster cells 4 (Xrcc4) 抗体
X-ray repair cross complementing 4 (Xrcc4) 抗体
2310057B22Rik 抗体
AW413319 抗体
AW545101 抗体
homolog of human DNA ligase iv-binding protein XRCC4 抗体
MGC81443 抗体
zgc:73312 抗体
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