XRCC4 产品
(X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4))
Categories
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008].
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Featured XRCC4 Categories
XRCC4 抗体
High quality antibodies with extensive validation data.
XRCC4 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
XRCC4 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended XRCC4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (2)
- (7)
Cat. No.
ABIN3022382
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (1)
- (5)
Cat. No.
ABIN1327721
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (4)
Cat. No.
ABIN7259376
Quantity
200 μL
Datasheet
Datasheet
Recommended XRCC4 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381600
Quantity
96 tests
Datasheet
Datasheet
Recommended XRCC4 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325469
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325471
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2735698
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our XRCC4 Products
: "Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability." in: Journal of cell science, Vol. 131, Issue 12, (2018) (PubMed).: "Quantitative proteomic analysis revealed changes in protein synthesis and mitochondrial functions after acute DNA damage in mouse neural stem cells." in: Neuroscience letters, Vol. 653, pp. 355-361, (2018) (PubMed).
: "Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes." in: Nature communications, Vol. 7, pp. 13049, (2018) (PubMed).
: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).
: "Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining." in: Nucleic acids research, Vol. 45, Issue 18, pp. 10583-10594, (2017) (PubMed).
: "A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage." in: Genes & development, Vol. 29, Issue 11, pp. 1151-63, (2015) (PubMed).
: "Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 20, pp. E2575-84, (2015) (PubMed).
: "A stress-induced cellular aging model with postnatal neural stem cells." in: Cell death & disease, Vol. 5, pp. e1116, (2014) (PubMed).
: "Quantification of XRCC and DNA-PK proteins in cancer cell lines and human tumors by LC-MS/MS." in: Bioanalysis, Vol. 6, Issue 22, pp. 2969-83, (2014) (PubMed).
: "A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination." in: The Journal of experimental medicine, Vol. 210, Issue 12, pp. 2503-13, (2013) (PubMed).
Synonyms and alternative names related to XRCC4
X-ray repair cross complementing 4 (XRCC4), X-ray repair complementing defective repair in Chinese hamster cells 4 (xrcc4), X-ray repair complementing defective repair in Chinese hamster cells 4 L homeolog (xrcc4.L), DNA ligase IV-binding protein (XRCC4), X-ray repair complementing defective repair in Chinese hamster cells 4 (Xrcc4), X-ray repair cross complementing 4 (Xrcc4), 2310057B22Rik, AW413319, AW545101, homolog of human DNA ligase iv-binding protein XRCC4, MGC81443, zgc:73312Protein level used designations for XRCC4
- DNA repair protein XRCC4
- X-ray repair complementing defective repair in Chinese hamster cells 4
- DNA-repair protein XRCC4
- X-ray repair cross complementing protein 4
- X-ray repair cross-complementing protein 4
- X-ray repair, complementing defective, repair in Chinese hamster
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