XRCC3 产品
(X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3))
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This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
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Latest Publications for our XRCC3 Products
: "GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK." in: Developmental cell, Vol. 42, Issue 2, pp. 130-142.e7, (2017) (PubMed).: "The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression." in: Oncogene, Vol. 36, Issue 36, pp. 5168-5176, (2017) (PubMed).
: "NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability." in: Nucleic acids research, Vol. 43, Issue 20, pp. 9817-34, (2015) (PubMed).
: "A stress-induced cellular aging model with postnatal neural stem cells." in: Cell death & disease, Vol. 5, pp. e1116, (2014) (PubMed).
: "Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair." in: Oncogene, Vol. 33, Issue 40, pp. 4803-12, (2014) (PubMed).
: "Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity." in: Molecular cancer research : MCR, Vol. 11, Issue 12, pp. 1564-73, (2013) (PubMed).
: "Oxidative stress in mammalian cells impinges on the cysteines redox state of human XRCC3 protein and on its cellular localization." in: PLoS ONE, Vol. 8, Issue 10, pp. e75751, (2013) (PubMed).
: "Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta." in: Carcinogenesis, Vol. 33, Issue 11, pp. 2026-34, (2012) (PubMed).
: "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway." in: Molecular and cellular biology, Vol. 33, Issue 2, pp. 387-95, (2012) (PubMed).
: "Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome." in: The Journal of biological chemistry, Vol. 285, Issue 25, pp. 18984-90, (2010) (PubMed).
Synonyms and alternative names related to XRCC3
X-ray repair cross complementing 3 (XRCC3), X-ray repair complementing defective repair in Chinese hamster cells 3 (Xrcc3), X-ray repair complementing defective repair in Chinese hamster cells 3 L homeolog (xrcc3.L), X-ray repair complementing defective repair in Chinese hamster cells 3 (xrcc3), X-ray repair cross complementing 3 (Xrcc3), 4432412E01Rik, AI182522, AW537713, CMM6, im:7142103, MGC69118, si:dkey-11b8.1, xrcc3, XRCC3, zgc:101608Protein level used designations for XRCC3
- DNA repair protein XRCC3
- X-ray repair cross-complementing protein 3
- X-ray repair complementing defective repair in Chinese hamster cells 3
- DNA-repair protein XRCC3
- rCG27697-like
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