WRAP53 抗体
(WD Repeat Containing, Antisense To TP53 (WRAP53))
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011].
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WRAP53 抗体 by 适用
Find WRAP53 抗体 for a variety of species such as anti-Human WRAP53, anti-Mouse WRAP53, anti-Rat WRAP53. The species listed below are among those available. Click on a link to go to the corresponding products.
WRAP53 抗体 by 应用范围
Find WRAP53 抗体 validated for a specific application such as WB, IF (cc), IF (p), ELISA. Some of the available applications are listed below. Click on a link to go to the corresponding products.
WRAP53 抗体 by 抗体来源
Find WRAP53 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
WRAP53 抗体 by 抗原表位
Find WRAP53 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.
WRAP53 抗体 by 克隆形成能力
Find available monoclonal or polyclonal WRAP53 抗体. Click on a link to go to the corresponding products.
WRAP53 抗体 by 克隆
Find WRAP53 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.
Popular WRAP53 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (4)
Cat. No.
ABIN527367
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (3)
Cat. No.
ABIN527366
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
- (1)
Cat. No.
ABIN527365
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro)
Validations
- (1)
Cat. No.
ABIN873001
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN919946
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (p), IF (cc)
Validations
Cat. No.
ABIN5011429
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (p), IF (cc)
Validations
Cat. No.
ABIN919945
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (p), IF (cc)
Validations
Cat. No.
ABIN2806929
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (p), IF (cc)
Validations
Cat. No.
ABIN919957
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (p), IF (cc)
Validations
Cat. No.
ABIN919956
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (p), IF (cc)
Validations
Cat. No.
ABIN919955
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (p), IF (cc)
Validations
Cat. No.
ABIN5011430
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (p), IF (cc)
Validations
Cat. No.
ABIN919947
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (p), IF (cc)
Validations
Cat. No.
ABIN919948
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (p), IF (cc)
Validations
Cat. No.
ABIN919949
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our WRAP53 抗体
: "N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation." in: Nucleic acids research, Vol. 47, Issue 10, pp. 5368-5380, (2019) (PubMed).: "Clinical, cellular, and bioinformatic analyses reveal involvement of WRAP53 overexpression in carcinogenesis of lung adenocarcinoma." in: Tumour biology, Vol. 39, Issue 3, pp. 1010428317694309, (2017) (PubMed).
: "Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies." in: eLife, Vol. 5, (2016) (PubMed).
: "Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle." in: The Journal of biological chemistry, Vol. 290, Issue 35, pp. 21320-35, (2015) (PubMed).
: "Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA." in: Nucleic acids research, Vol. 43, Issue 3, pp. 1834-47, (2015) (PubMed).
: "Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome." in: Cell death & disease, Vol. 6, pp. e1892, (2015) (PubMed).
: "The scaffold protein WRAP53? orchestrates the ubiquitin response critical for DNA double-strand break repair." in: Genes & development, Vol. 28, Issue 24, pp. 2726-38, (2014) (PubMed).
: "TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas." in: Molecular cancer, Vol. 13, pp. 180, (2014) (PubMed).
: "Telomerase recruitment requires both TCAB1 and Cajal bodies independently." in: Molecular and cellular biology, Vol. 32, Issue 13, pp. 2384-95, (2012) (PubMed).
: "WRAP53 promotes cancer cell survival and is a potential target for cancer therapy." in: Cell death & disease, Vol. 2, pp. e114, (2011) (PubMed).
Aliases for WRAP53 抗体
WD repeat containing antisense to TP53 (WRAP53) 抗体WD repeat containing, antisense to TP53 (Wrap53) 抗体
WD repeat containing, antisense to Trp53 (Wrap53) 抗体
BC021790 抗体
DKCB3 抗体
TCAB1 抗体
WDR79 抗体
Wdr79 抗体
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