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WNK4 产品

(WNK Lysine Deficient Protein Kinase 4 (WNK4))
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009].

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Featured WNK4 Categories

WNK4 抗体

High quality antibodies with extensive validation data.

WNK4 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended WNK4 抗体

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Reactivity Human
Application ELISA, IHC, IF
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Cat. No. ABIN7169234
Quantity 100 μg
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Application ELISA, WB
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Cat. No. ABIN528800
Quantity 100 μg
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Cat. No. ABIN668526
Quantity 100 μL
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Recommended WNK4 蛋白

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Quantity 10 μg
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Source Insect Cells
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Cat. No. ABIN5509230
Quantity 10 μg
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Source Tobacco (Nicotiana tabacum)
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Latest Publications for our WNK4 Products

Huguet, Le Dudal, Livrozet, Bazin, Frochot, Perez, Haymann, Brocheriou, Daudon, Letavernier: "High frequency and wide range of human kidney papillary crystalline plugs." in: Urolithiasis, (2018) (PubMed).

Kim, Yang, Kim, Kang, Kim, Cho: "Role of nitric oxide and WNK-SPAK/OSR1-KCC2 signaling in daily changes in GABAergic inhibition in the rat dorsal raphe neurons." in: Neuropharmacology, Vol. 135, pp. 355-367, (2018) (PubMed).

Bhuiyan, Song, Yuan, Begum, Kofler, Kahle, Yang, Lin, Alper, Subramanya, Sun: "WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 37, Issue 8, pp. 2780-2794, (2017) (PubMed).

Li, Hatano, Xu, Wan, Yang, Weinstein, Palmer, Wang: "Gender difference in kidney electrolyte transport. I. Role of AT1a receptor in thiazide-sensitive Na+-Cl- cotransporter activity and expression in male and female mice." in: American journal of physiology. Renal physiology, Vol. 313, Issue 2, pp. F505-F513, (2017) (PubMed).

Andrukhova, Smorodchenko, Egerbacher, Streicher, Zeitz, Goetz, Shalhoub, Mohammadi, Pohl, Lanske, Erben: "FGF23 promotes renal calcium reabsorption through the TRPV5 channel." in: The EMBO journal, Vol. 33, Issue 3, pp. 229-46, (2014) (PubMed).

Ohno, Uchida, Ohashi, Nitta, Ohta, Chiga, Sasaki, Uchida: "Immunolocalization of WNK4 in mouse kidney." in: Histochemistry and cell biology, Vol. 136, Issue 1, pp. 25-35, (2011) (PubMed).

Uchida: "Pathophysiological roles of WNK kinases in the kidney." in: Pflügers Archiv : European journal of physiology, Vol. 460, Issue 4, pp. 695-702, (2010) (PubMed).

Subramanya, Liu, Ellison, Wade, Welling: "WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction." in: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18471-80, (2009) (PubMed).

Song, Hu, Riazi, Tiwari, Wade, Ecelbarger: "Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats." in: American journal of physiology. Renal physiology, Vol. 290, Issue 5, pp. F1055-64, (2006) (PubMed).

Kahle, Gimenez, Hassan, Wilson, Wong, Forbush, Aronson, Lifton: "WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 7, pp. 2064-9, (2004) (PubMed).

Synonyms and alternative names related to WNK4

WNK lysine deficient protein kinase 4 (WNK4), WNK lysine deficient protein kinase 4 (Wnk4), 2010002J11Rik, Ac2-059, PHA2B, Pha2b, PRKWNK4, Prkwnk4, WNK4

Protein level used designations for WNK4

  • WNK lysine deficient protein kinase 4
  • protein kinase lysine-deficient 4
  • protein kinase with no lysine 4
  • serine/threonine-protein kinase WNK4
  • protein kinase, lysine deficient 4
  • WNK4 Ser/Thr kinase
  • protein kinase, lysine-deficient 4
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