WISP1 产品
(WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
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This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011].
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Featured WISP1 Categories
WISP1 抗体
High quality antibodies with extensive validation data.
WISP1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
WISP1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended WISP1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, FACS
Validations
- (7)
Cat. No.
ABIN238610
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7436372
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, IF
Validations
- (4)
Cat. No.
ABIN7175846
Quantity
100 μg
Datasheet
Datasheet
Recommended WISP1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6962685
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960559
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960558
Quantity
96 tests
Datasheet
Datasheet
Recommended WISP1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275850
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325341
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7399112
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our WISP1 Products
: "Tao-Hong-Si-Wu Decoction promotes angiogenesis after cerebral ischaemia in rats via platelet microparticles." in: Chinese journal of natural medicines, Vol. 18, Issue 8, pp. 620-627, (2020) (PubMed).: "Based on HIF-1α/Wnt/β-Catenin Pathway to Explore the Effect of Qingshen Granules on Chronic Renal Failure Patients: A Randomized Controlled Trial." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2019, pp. 7656105, (2019) (PubMed).
: "Resveratrol Attenuates Hyperoxia-induced Oxidative Stress, Inflammation and Fibrosis and Suppresses Wnt/?-catenin Signaling in Lungs of Neonatal Rats." in: Clinical and experimental pharmacology & physiology, (2015) (PubMed).
: "WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-? pathways." in: British journal of cancer, Vol. 113, Issue 6, pp. 921-33, (2015) (PubMed).
: "miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis." in: The international journal of biochemistry & cell biology, Vol. 53, pp. 432-41, (2014) (PubMed).
: "WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death." in: The Journal of biological chemistry, Vol. 284, Issue 21, pp. 14414-27, (2009) (PubMed).
: "Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling." in: Science (New York, N.Y.), Vol. 316, Issue 5827, pp. 1043-6, (2007) (PubMed).
: "Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation." in: The Journal of biological chemistry, Vol. 278, Issue 13, pp. 11465-70, (2003) (PubMed).
: "Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma." in: Hepatology (Baltimore, Md.), Vol. 37, Issue 5, pp. 1122-9, (2003) (PubMed).
: "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)." in: The EMBO journal, Vol. 22, Issue 12, pp. 3084-94, (2003) (PubMed).
Synonyms and alternative names related to WISP1
WNT1 inducible signaling pathway protein 1 (WISP1), WNT1 inducible signaling pathway protein 1a (wisp1a), WNT1 inducible signaling pathway protein 1 (Wisp1), WNT1-inducible-signaling pathway protein 1-like (LOC100627044), WNT1 inducible signaling pathway protein 1b (wisp1b), AW146261, CCN4, Elm1, si:ch211-38f10.2, WISP-1, WISP1, WISP1c, WISP1i, WISP1tc, zgc:172276Protein level used designations for WISP1
- CCN family member 4
- WNT1 induced secreted protein 1
- WNT1-inducible-signaling pathway protein 1
- Wnt-1 inducible signaling pathway protein 1
- Wnt-1-induced secreted protein
- WNT1 inducible signaling pathway protein 1
- wisp1
- zWISP1-c19
- ELM-1
- WISP-1
- zWISP1-c16
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