WHSC1 产品
(Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1))
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This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008].
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Recommended WHSC1 抗体
Product
Reactivity
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Datasheet
Reactivity
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Application
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Cat. No.
ABIN521379
Quantity
50 μg
Datasheet
Datasheet
Reactivity
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Application
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Cat. No.
ABIN6150213
Quantity
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Datasheet
Datasheet
Reactivity
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Cat. No.
ABIN7155501
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Datasheet
Datasheet
Recommended WHSC1 蛋白
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Cat. No.
ABIN7125739
Quantity
50 μg
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Wheat germ
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Cat. No.
ABIN1325322
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ABIN2669701
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20 μg
Datasheet
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Latest Publications for our WHSC1 Products
: "The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies. ..." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 25, Issue 1, pp. 300-311, (2019) (PubMed).: "MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication." in: Cell cycle (Georgetown, Tex.), Vol. 15, Issue 1, pp. 95-105, (2016) (PubMed).
: "NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation." in: Scientific reports, Vol. 6, pp. 32952, (2016) (PubMed).
: "NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma." in: Cancer research, Vol. 73, Issue 20, pp. 6277-88, (2013) (PubMed).
: "The histone methyltransferase MMSET regulates class switch recombination." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 2, pp. 756-63, (2013) (PubMed).
: "Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway." in: Neoplasia (New York, N.Y.), Vol. 13, Issue 10, pp. 887-98, (2011) (PubMed).
: "The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas." in: Cancer genomics & proteomics, Vol. 5, Issue 6, pp. 293-300, (2009) (PubMed).
: "Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas." in: Neuro-oncology, Vol. 10, Issue 1, pp. 45-51, (2008) (PubMed).
: "The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor." in: Blood, Vol. 111, Issue 6, pp. 3145-54, (2008) (PubMed).
Synonyms and alternative names related to WHSC1
nuclear receptor binding SET domain protein 2 (NSD2), nuclear receptor binding SET domain protein 2 (nsd2), Wolf-Hirschhorn syndrome candidate 1 (WHSC1), nuclear receptor binding SET domain protein 2 (Nsd2), 5830445G22Rik, 9430010A17Rik, AW555663, C130020C13Rik, D030027O06Rik, D930023B08Rik, fc12c04, mKIAA1090, mmset, MMSET, nsd2, NSD2, reiibp, REIIBP, RGD1565590, si:rp71-77d7.2, trx5, TRX5, whs, WHS, WHSC1, Whsc1l, wu:fc12c04, wu:fi20c01Protein level used designations for WHSC1
- Wolf-Hirschhorn syndrome candidate 1 protein
- Wolf-Hirschhorn syndrome candidate 1
- probable histone-lysine N-methyltransferase NSD2
- IL5 promoter REII region-binding protein
- histone-lysine N-methyltransferase NSD2
- multiple myeloma SET domain containing protein type III
- nuclear SET domain-containing protein 2
- trithorax/ash1-related protein 5
- multiple myeloma SET domain-containing protein
- wolf-Hirschhorn syndrome candidate 1 protein homolog
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