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WFDC2 产品

(WAP Four-Disulfide Core Domain 2 (WFDC2))
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured WFDC2 Categories

WFDC2 抗体

High quality antibodies with extensive validation data.

WFDC2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

WFDC2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended WFDC2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse, Rat
Application ELISA, WB, IHC (p)
Validations
  • (6)
Cat. No. ABIN5519074
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN7175671
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IHC (p)
Validations
  • (4)
Cat. No. ABIN1491389
Quantity 100 μL
Datasheet Datasheet

Recommended WFDC2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962650
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960523
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6976023
Quantity 96 tests
Datasheet Datasheet

Recommended WFDC2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Dog
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7274791
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1325310
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125722
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our WFDC2 Products

Yang, Lu, Guo, Fellman, Ning, Lu, Menon, Kobayashi, Hanash, Celestino, Skates, Bast: "Human epididymis protein 4 antigen-autoantibody complexes complement cancer antigen 125 for detecting early-stage ovarian cancer." in: Cancer, (2019) (PubMed).

Dong, Liu, Li: "Value of HE4 Combined with Cancer Antigen 125 in the Diagnosis of Endometrial Cancer." in: Pakistan journal of medical sciences, Vol. 33, Issue 4, pp. 1013-1017, (2017) (PubMed).

Zhou, Lv, Shao, Xu, Luo, Zhang, Hu, Zhang, Luo, Fang, Wang, Duan, Huang: "Detection of Human Epididymis Protein 4 (HE4) in Human Serum Samples Using a Specific Monoclonal Antibody-Based Sandwich Enzyme-Linked Immunosorbent Assay (ELISA)." in: Journal of clinical laboratory analysis, Vol. 30, Issue 5, pp. 581-9, (2017) (PubMed).

Eaton, Shallcross, Mael, Mears, Minkoff, Scoville, Whelan: "Selection of DNA aptamers for ovarian cancer biomarker HE4 using CE-SELEX and high-throughput sequencing." in: Analytical and bioanalytical chemistry, (2015) (PubMed).

Moore, Hill, Horan, Yano, Kim, MacLaughlan, Lambert-Messerlian, Tseng, Padbury, Miller, Lange, Singh: "HE4 (WFDC2) gene overexpression promotes ovarian tumor growth." in: Scientific reports, Vol. 4, pp. 3574, (2014) (PubMed).

LeBleu, Teng, OConnell, Charytan, Müller, Müller, Sugimoto, Kalluri: "Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis." in: Nature medicine, Vol. 19, Issue 2, pp. 227-31, (2013) (PubMed).

Yuan, Duan, Yang, Luo, Xi: "Detection of serum human epididymis secretory protein 4 in patients with ovarian cancer using a label-free biosensor based on localized surface plasmon resonance." in: International journal of nanomedicine, Vol. 7, pp. 2921-8, (2012) (PubMed).

Huhtinen, Suvitie, Hiissa, Junnila, Huvila, Kujari, Setälä, Härkki, Jalkanen, Fraser, Mäkinen, Auranen, Poutanen, Perheentupa: "Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts." in: British journal of cancer, Vol. 100, Issue 8, pp. 1315-9, (2009) (PubMed).

Hellström, Raycraft, Hayden-Ledbetter, Ledbetter, Schummer, McIntosh, Drescher, Urban, Hellström: "The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma." in: Cancer research, Vol. 63, Issue 13, pp. 3695-700, (2003) (PubMed).

Kirchhoff, Habben, Ivell, Krull: "A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors." in: Biology of reproduction, Vol. 45, Issue 2, pp. 350-7, (1992) (PubMed).

Synonyms and alternative names related to WFDC2

WAP four-disulfide core domain 2 (WFDC2), WAP four-disulfide core domain 2 (wfdc2), WAP four-disulfide core domain 2 (Wfdc2), 1600023A02Rik, BE-20, CE4, dJ461P17.6, EDDM4, HE4, re4, si:ch211-153a8.3, WAP5, WFDC2, WFDC3

Protein level used designations for WFDC2

  • WAP four-disulfide core domain 2
  • WAP four-disulfide core domain 3
  • WAP four-disulfide core domain protein 2
  • WAP domain containing protein HE4-V4
  • epididymal protein 4
  • epididymal secretory protein E4
  • epididymis-specific, whey-acidic protein type, four-disulfide core
  • major epididymis-specific protein E4
  • putative protease inhibitor WAP5
  • WAP domain-containing protein HE4
  • epididymal secretory protein 4
  • epididymal protein BE-20
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