VRK1 抗体
(Vaccinia Related Kinase 1 (VRK1))
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008].
recommended
VRK1 适用: 人 WB, ELISA, IP, IF, RNAi 宿主: 小鼠 Monoclonal 4F9 unconjugated
recommended
recommended
VRK1 抗体 by 适用
Find VRK1 抗体 for a variety of species such as anti-Human VRK1, anti-Mouse VRK1, anti-Rat VRK1. The species listed below are among those available. Click on a link to go to the corresponding products.
VRK1 抗体 by 应用范围
Find VRK1 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.
VRK1 抗体 by 抗体来源
Find VRK1 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
VRK1 抗体 by 克隆形成能力
Find available monoclonal or polyclonal VRK1 抗体. Click on a link to go to the corresponding products.
VRK1 抗体 by 克隆
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Popular VRK1 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
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Application
WB, ELISA, IP, IF, RNAi
Validations
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Cat. No.
ABIN521352
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IP, IF
Validations
- (11)
Cat. No.
ABIN2452161
Quantity
100 μg
Datasheet
Datasheet
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Application
WB, ELISA, IHC
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- (3)
Cat. No.
ABIN7169217
Quantity
100 μL
Datasheet
Datasheet
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Application
WB, IP
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- (3)
Cat. No.
ABIN521350
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN521349
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7252186
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN2737815
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB
Validations
- (1)
Cat. No.
ABIN4915154
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN6266002
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN563378
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB
Validations
- (2)
Cat. No.
ABIN3044560
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC
Validations
- (2)
Cat. No.
ABIN1860946
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
Cat. No.
ABIN872861
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN919824
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN919836
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our VRK1 抗体
: "VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle." in: Scientific reports, Vol. 5, pp. 10543, (2015) (PubMed).: "Depletion of the protein kinase VRK1 disrupts nuclear envelope morphology and leads to BAF retention on mitotic chromosomes." in: Molecular biology of the cell, Vol. 25, Issue 6, pp. 891-903, (2014) (PubMed).
: "Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response." in: Oncotarget, Vol. 5, Issue 7, pp. 1770-8, (2014) (PubMed).
: "Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo." in: Oncogenesis, Vol. 2, pp. e48, (2013) (PubMed).
: "Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas." in: Nature communications, Vol. 4, pp. 1701, (2013) (PubMed).
: "Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage." in: The Journal of biological chemistry, Vol. 287, Issue 28, pp. 23757-68, (2012) (PubMed).
: "The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines." in: The FEBS journal, Vol. 273, Issue 11, pp. 2487-504, (2006) (PubMed).
: "Characterization of three paralogous members of the Mammalian vaccinia related kinase family." in: The Journal of biological chemistry, Vol. 279, Issue 9, pp. 7934-46, (2004) (PubMed).
: "Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1." in: Archives of biochemistry and biophysics, Vol. 399, Issue 1, pp. 1-5, (2002) (PubMed).
: "The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein." in: Oncogene, Vol. 19, Issue 32, pp. 3656-64, (2000) (PubMed).
Aliases for VRK1 抗体
vaccinia related kinase 1 L homeolog (vrk1.L) 抗体vaccinia related kinase 1 (vrk1) 抗体
vaccinia related kinase 1 (VRK1) 抗体
Serine/threonine-protein kinase VRK1 (vrk-1) 抗体
vaccinia related kinase 1 (Vrk1) 抗体
51PK 抗体
MGC64390 抗体
MGC75762 抗体
PCH1 抗体
PCH1A 抗体
vrk1 抗体
VRK1 抗体
wu:fe16f06 抗体
zgc:56266 抗体
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