VHLL 产品
(Von Hippel-Lindau Tumor Suppressor-Like (VHLL))
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Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010].
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Featured VHLL Categories
Recommended VHLL 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7175638
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN1327492
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
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Quantity
100 μg
Datasheet
Datasheet
Recommended VHLL 蛋白
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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3075289
Quantity
1 mg
Datasheet
Datasheet
Synonyms and alternative names related to VHLL
VHL like (VHLL), VHLP, VLPProtein level used designations for VHLL
- VHL pseudogene
- VHL-like protein
- von Hippel-Lindau-like protein
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