VHL 抗体
(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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VHL 抗体 by Grade
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VHL 抗体 by 克隆
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Popular VHL 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (3)
- (6)
Cat. No.
ABIN3020968
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), IP, ICC
Validations
- (1)
- (8)
Cat. No.
ABIN2854928
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p)
Validations
- (8)
Cat. No.
ABIN1501712
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7441592
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IF, IHC (p)
Validations
- (7)
Cat. No.
ABIN390462
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, ELISA, FACS, IF
Validations
- (6)
Cat. No.
ABIN3029605
Quantity
0.2 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN563371
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (2)
- (4)
Cat. No.
ABIN390463
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, FACS
Validations
- (5)
Cat. No.
ABIN3029606
Quantity
0.4 mL
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Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN185675
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA
Validations
- (2)
Cat. No.
ABIN7189407
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN521328
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (2)
Cat. No.
ABIN7271338
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, FACS, IF/ICC
Validations
- (3)
Cat. No.
ABIN2905637
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
Cat. No.
ABIN872573
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our VHL 抗体
: "Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis." in: Scientific reports, Vol. 6, pp. 32131, (2018) (PubMed).: "VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2." in: Nature communications, Vol. 8, pp. 15337, (2018) (PubMed).
: "Salidroside accelerates fracture healing through cell-autonomous and non-autonomous effects on osteoblasts." in: Cell and tissue research, Vol. 367, Issue 2, pp. 197-211, (2017) (PubMed).
: "Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL)." in: The Journal of biological chemistry, Vol. 291, Issue 49, pp. 25692-25705, (2017) (PubMed).
: "An ID2-dependent mechanism for VHL inactivation in cancer." in: Nature, Vol. 529, Issue 7585, pp. 172-7, (2016) (PubMed).
: "Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta." in: Endocrinology, Vol. 156, Issue 8, pp. 3012-25, (2015) (PubMed).
: "HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression." in: In vitro cellular & developmental biology. Animal, Vol. 51, Issue 8, pp. 808-14, (2015) (PubMed).
: "pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 4, pp. 1782-90, (2015) (PubMed).
: "The von hippel-lindau protein suppresses androgen receptor activity." in: Molecular endocrinology (Baltimore, Md.), Vol. 28, Issue 2, pp. 239-48, (2015) (PubMed).
: "Hypoxia inducible factor-1α suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells." in: FEBS letters, Vol. 588, Issue 18, pp. 3390-4, (2014) (PubMed).
Aliases for VHL 抗体
von Hippel-Lindau tumor suppressor (VHL) 抗体von Hippel-Lindau (Vhl) 抗体
von Hippel-Lindau tumor suppressor (vhl) 抗体
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL) 抗体
von Hippel-Lindau disease tumor suppressor (CpipJ_CPIJ009992) 抗体
von Hippel-Lindau tumor suppressor (Vhl) 抗体
BcDNA:RH61560 抗体
CG13221 抗体
d-VHL 抗体
d-vhl 抗体
Dmel\\CG13221 抗体
dmVHL 抗体
DVhl 抗体
Dvhl 抗体
dVHL 抗体
HRCA1 抗体
hrca1 抗体
pVHL 抗体
RCA1 抗体
rca1 抗体
VHL 抗体
vhl 抗体
VHL1 抗体
vhl1 抗体
Vhlh 抗体
zgc:158722 抗体
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