USP7 抗体
(Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity).
recommended
recommended
USP7 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Monoclonal 7F10 unconjugated Recombinant Antibody
recommended
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USP7 抗体 by 克隆形成能力
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Popular USP7 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
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Application
WB, IHC, IP, ICC
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Cat. No.
ABIN7443551
Quantity
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Datasheet
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Reactivity
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Application
WB, IHC, ELISA, IF
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, IHC, IF
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Cat. No.
ABIN6150031
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
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Cat. No.
ABIN3023238
Quantity
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Datasheet
Datasheet
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Application
IHC
Validations
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Cat. No.
ABIN7257168
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (3)
Cat. No.
ABIN6265935
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Chicken, Dog, Horse, Human, Macaque, Mouse, Rat
Application
WB, IHC, IHC (p)
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- (3)
Cat. No.
ABIN960399
Quantity
50 μg
Datasheet
Datasheet
Reactivity
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Application
WB, IHC, ELISA
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Cat. No.
ABIN5693267
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
IHC, ELISA, IF
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Cat. No.
ABIN7174356
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB
Validations
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Cat. No.
ABIN960400
Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
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- (1)
Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN129596
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN388889
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (1)
- (2)
Cat. No.
ABIN2787924
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF, IC
Validations
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Cat. No.
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Quantity
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Datasheet
Datasheet
Latest Publications for our USP7 抗体
: "Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation." in: Biology of reproduction, Vol. 94, Issue 2, pp. 31, (2016) (PubMed).: "The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60." in: Nature communications, Vol. 6, pp. 6752, (2015) (PubMed).
: "Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains." in: Journal of virology, Vol. 89, Issue 20, pp. 10260-72, (2015) (PubMed).
: "Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)." in: BMC cancer, Vol. 12, Issue 1, pp. 342, (2012) (PubMed).
: "Alternate splicing of the p53 inhibitor HDMX offers a superior prognostic biomarker than p53 mutation in human cancer." in: Cancer research, Vol. 72, Issue 16, pp. 4074-84, (2012) (PubMed).
: "Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts." in: Mechanisms of ageing and development, Vol. 133, Issue 7, pp. 498-507, (2012) (PubMed).
: "The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation." in: The EMBO journal, Vol. 31, Issue 17, pp. 3596-606, (2012) (PubMed).
: "KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR)." in: The Journal of biological chemistry, Vol. 287, Issue 42, pp. 35118-26, (2012) (PubMed).
: "High levels of Hdmx promote cell growth in a subset of uveal melanomas." in: American journal of cancer research, Vol. 2, Issue 5, pp. 492-507, (2012) (PubMed).
: "UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair." in: Nature genetics, Vol. 44, Issue 5, pp. 598-602, (2012) (PubMed).
Aliases for USP7 抗体
Ubiquitin-specific protease 7 (Usp7) 抗体ubiquitin carboxyl-terminal hydrolase 7 (LOC100201254) 抗体
ubiquitin specific peptidase 7 (USP7) 抗体
ubiquitin specific peptidase 7 (Usp7) 抗体
2210010O09Rik 抗体
AA409944 抗体
AA617399 抗体
AU019296 抗体
AW548146 抗体
C80752 抗体
CG1490 抗体
Dmel\\CG1490 抗体
Hausp 抗体
HAUSP 抗体
TEF1 抗体
UBP 抗体
USP7 抗体
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