USP7 产品
(Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
Categories
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity).
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Featured USP7 Categories
Recommended USP7 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7443551
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, IF
Validations
- (4)
Cat. No.
ABIN7127535
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN6150031
Quantity
100 μL
Datasheet
Datasheet
Recommended USP7 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125598
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324846
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7416877
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our USP7 Products
: "Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation." in: Biology of reproduction, Vol. 94, Issue 2, pp. 31, (2016) (PubMed).: "The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60." in: Nature communications, Vol. 6, pp. 6752, (2015) (PubMed).
: "Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains." in: Journal of virology, Vol. 89, Issue 20, pp. 10260-72, (2015) (PubMed).
: "HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation." in: Nucleic acids research, Vol. 42, Issue 9, pp. 5582-93, (2014) (PubMed).
: "Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)." in: BMC cancer, Vol. 12, Issue 1, pp. 342, (2012) (PubMed).
: "Alternate splicing of the p53 inhibitor HDMX offers a superior prognostic biomarker than p53 mutation in human cancer." in: Cancer research, Vol. 72, Issue 16, pp. 4074-84, (2012) (PubMed).
: "Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts." in: Mechanisms of ageing and development, Vol. 133, Issue 7, pp. 498-507, (2012) (PubMed).
: "The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation." in: The EMBO journal, Vol. 31, Issue 17, pp. 3596-606, (2012) (PubMed).
: "KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR)." in: The Journal of biological chemistry, Vol. 287, Issue 42, pp. 35118-26, (2012) (PubMed).
: "High levels of Hdmx promote cell growth in a subset of uveal melanomas." in: American journal of cancer research, Vol. 2, Issue 5, pp. 492-507, (2012) (PubMed).
Synonyms and alternative names related to USP7
Ubiquitin-specific protease 7 (Usp7), ubiquitin carboxyl-terminal hydrolase 7 (LOC100201254), ubiquitin specific peptidase 7 (USP7), ubiquitin specific peptidase 7 (Usp7), 2210010O09Rik, AA409944, AA617399, AU019296, AW548146, C80752, CG1490, Dmel\\CG1490, Hausp, HAUSP, TEF1, UBP, USP7Protein level used designations for USP7
- CG1490-PB
- Usp7-PB
- ubiquitin specific peptidase 7 (herpes virus-associated)
- ubiquitin carboxyl-terminal hydrolase 7-like
- deubiquitinating enzyme 7
- herpesvirus-associated ubiquitin-specific protease
- mHAUSP
- ubiquitin carboxyl-terminal hydrolase 7
- ubiquitin specific protease 7
- ubiquitin thioesterase 7
- ubiquitin thiolesterase 7
- ubiquitin-specific-processing protease 7
- Herpes virus-associated ubiquitin-specific protease
- ubiquitin specific protease 7 (herpes virus-associated)
- herpes-virus-associated ubiquitin-specific protease
- rHAUSP
- ubiquitin-specific peptidase 7
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