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USP18 产品

(Ubiquitin Specific Peptidase 18 (USP18))

Categories

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011].

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Featured USP18 Categories

USP18 抗体

High quality antibodies with extensive validation data.

USP18 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

USP18 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended USP18 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, IHC
Validations
  • (6)
Cat. No. ABIN7271145
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC
Validations
  • (4)
Cat. No. ABIN7174583
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF, IHC
Validations
  • (4)
Cat. No. ABIN7076108
Quantity 100 μL
Datasheet Datasheet

Recommended USP18 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6971043
Quantity 96 tests
Datasheet Datasheet

Recommended USP18 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125590
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324763
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324762
Quantity 25 μg
Datasheet Datasheet

Latest Publications for our USP18 Products

Ganesan, Poluektova, Tuma, Kharbanda, Osna: "Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18." in: Alcoholism, clinical and experimental research, Vol. 40, Issue 11, pp. 2329-2338, (2016) (PubMed).

Synonyms and alternative names related to USP18

ubiquitin specific peptidase 18 (USP18), ubiquitin specific peptidase 18 (Usp18), 1110058H21Rik, AW047653, bubp43, ISG43, UBP, Ubp15, UBP43, USP18, USP41

Protein level used designations for USP18

  • 43 kDa ISG15-specific protease
  • ISG15-specific-processing protease
  • hUBP43
  • ubiquitin specific protease 18
  • ubl carboxyl-terminal hydrolase 18
  • ubl thioesterase 18
  • ubl thiolesterase 18
  • ubiquitin specific peptidase 18
  • ubiquitin specific protease 15
  • interferon-stimulated gene 43
  • ubiquitin-specific protease 18
  • ubiquitin specific peptidase 41
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