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USP15 产品

(Ubiquitin Specific Peptidase 15 (USP15))

Categories

This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011].

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Featured USP15 Categories

USP15 抗体

High quality antibodies with extensive validation data.

USP15 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended USP15 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (9)
  • (5)
Cat. No. ABIN564282
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (4)
Cat. No. ABIN2855881
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IF, IHC (p)
Validations
  • (5)
Cat. No. ABIN388904
Quantity 400 μL
Datasheet Datasheet

Recommended USP15 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6222175
Quantity 96 tests
Datasheet Datasheet

Recommended USP15 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125589
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324756
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2132480
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our USP15 Products

Oikonomaki, Bady, Hegi: "Ubiquitin Specific Peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity." in: Oncotarget, Vol. 8, Issue 66, pp. 110490-110502, (2018) (PubMed).

Zhang, Wang, Zhong, Luo, Shang, Liu, Chen, Fang, Xiao: "Ubiquitin-specific Protease 15 Negatively Regulates Virus-induced Type I Interferon Signaling via Catalytically-dependent and -independent Mechanisms." in: Scientific reports, Vol. 5, pp. 11220, (2016) (PubMed).

Pauli, Chan, Davis, Gableske, Wang, Feister, Gack: "The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25." in: Science signaling, Vol. 7, Issue 307, pp. ra3, (2014) (PubMed).

García-Caballero, Gadotti, Stemkowski, Weiss, Souza, Hodgkinson, Bladen, Chen, Hamid, Pizzoccaro, Deage, François, Bourinet, Zamponi: "The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity." in: Neuron, Vol. 83, Issue 5, pp. 1144-58, (2014) (PubMed).

Cornelissen, Haddad, Wauters, Van Humbeeck, Mandemakers, Koentjoro, Sue, Gevaert, De Strooper, Verstreken, Vandenberghe: "The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy." in: Human molecular genetics, Vol. 23, Issue 19, pp. 5227-42, (2014) (PubMed).

Goncharov, Niessen, de Almagro, Izrael-Tomasevic, Fedorova, Varfolomeev, Arnott, Deshayes, Kirkpatrick, Vucic: "OTUB1 modulates c-IAP1 stability to regulate signalling pathways." in: The EMBO journal, Vol. 32, Issue 8, pp. 1103-14, (2013) (PubMed).

Isumi, Hirata, Saitoh, Miyakawa, Murakami, Kudoh, Doi, Ishibashi, Nakajima: "Transgenic overexpression of USP15 in the heart induces cardiac remodeling in mice." in: Biochemical and biophysical research communications, Vol. 405, Issue 2, pp. 216-21, (2011) (PubMed).

Fernandez-Sanchez, Sechet, Margottin-Goguet, Rogge, Bianchi: "The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation." in: The Journal of biological chemistry, Vol. 285, Issue 23, pp. 17390-7, (2010) (PubMed).

Vos, Altreuter, White, Howley: "The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability." in: Journal of virology, Vol. 83, Issue 17, pp. 8885-92, (2009) (PubMed).

Xu, Takanashi, Oikawa, Tanaka, Nishi, Isaka, Kudo, Kuroda: "USP15 plays an essential role for caspase-3 activation during Paclitaxel-induced apoptosis." in: Biochemical and biophysical research communications, Vol. 388, Issue 2, pp. 366-71, (2009) (PubMed).

Synonyms and alternative names related to USP15

ubiquitin specific peptidase 15 (USP15), universal stress protein UspA (RR_RS05795), ubiquitin carboxyl-terminal hydrolase 15 (LOC100090554), ubiquitin specific peptidase 15 (usp15), ubiquitin specific peptidase 15 (Usp15), 4921514G19Rik, AI327321, E430033I05Rik, Gcap18, mKIAA0529, Ubp109, UNP, UNPH-2, UNPH4, USP15

Protein level used designations for USP15

  • ubiquitin specific peptidase 15
  • universal stress protein
  • ubiquitin carboxyl-terminal hydrolase 15-like
  • ubiquitin carboxyl-terminal hydrolase 15
  • ubiquitin specific protease 15
  • ubiquitous nuclear protein
  • Deubiquitinating enzyme 15
  • Ubiquitin thioesterase 15
  • Ubiquitin-specific-processing protease 15
  • deubiquitinating enzyme 15
  • ubiquitin thioesterase 15
  • ubiquitin-specific-processing protease 15
  • ubiquitin thiolesterase 15
  • granule cell antiserum positive 18
  • deubiquitinating enzyme Ubp109
  • ubiquitin carboxyl-terminal hydrolase of 109 kDa
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