USP13 产品
(Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13))
Categories
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro\; however, additional experiments are required to confirm such data (By similarity).
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Featured USP13 Categories
Recommended USP13 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN6258346
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (2)
Cat. No.
ABIN7184323
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Horse, Human, Monkey, Mouse
Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN1104942
Quantity
50 μg
Datasheet
Datasheet
Recommended USP13 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6222171
Quantity
96 tests
Datasheet
Datasheet
Recommended USP13 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324750
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3096193
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2712394
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our USP13 Products
: "Hypermethylation of genes in testicular embryonal carcinomas." in: British journal of cancer, Vol. 114, Issue 2, pp. 230-6, (2016) (PubMed).: "Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model." in: Proteome science, Vol. 9, pp. 73, (2011) (PubMed).
: "Human and mouse proteases: a comparative genomic approach." in: Nature reviews. Genetics, Vol. 4, Issue 7, pp. 544-58, (2003) (PubMed).
Synonyms and alternative names related to USP13
ubiquitin specific peptidase 13 (USP13), ubiquitin specific peptidase 13 (isopeptidase T-3) (Usp13), ubiquitin specific peptidase 13 (isopeptidase T-3) (USP13), ubiquitin specific peptidase 13 (usp13), ubiquitin specific peptidase 13 (isopeptidase T-3) (usp13), ubiquitin carboxyl-terminal hydrolase 13 (MGYG_01656), universal stress protein (RR_RS02895), 2700071E21Rik, AI848077, IsoT-3, ISOT3, MGC163140, usp13Protein level used designations for USP13
- deubiquitinating enzyme 13
- isopeptidase T-3
- ubiquitin carboxyl-terminal hydrolase 13
- ubiquitin specific protease 13 (isopeptidase T-3)
- ubiquitin thioesterase 13
- ubiquitin thiolesterase 13
- ubiquitin-specific-processing protease 13
- ubiquitin specific peptidase 13 (isopeptidase T-3)
- ubiquitin carboxyl-terminal hydrolase 13-like
- ubiquitin thiolesterase 13-like
- Deubiquitinating enzyme 13
- Ubiquitin thioesterase 13
- Ubiquitin-specific-processing protease 13
- ubiquitin specific peptidase 13
- universal stress protein
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