Uromodulin 产品
(Uromodulin (UMOD))
Categories
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008].
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Featured Uromodulin Categories
Uromodulin 抗体
High quality antibodies with extensive validation data.
Uromodulin ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Uromodulin 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Uromodulin 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IHC (fro), FACS, IF (p), IF (cc)
Validations
- (2)
- (4)
Cat. No.
ABIN678473
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IP
Validations
- (2)
- (4)
Cat. No.
ABIN521253
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Dog
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7437641
Quantity
100 μL
Datasheet
Datasheet
Recommended Uromodulin ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6960396
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6960397
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971085
Quantity
96 tests
Datasheet
Datasheet
Recommended Uromodulin 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324635
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324633
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505005
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Uromodulin Products
: "The effect of O-1602, a GPR55 agonist, on the cyclophosphamide-induced rat hemorrhagic cystitis." in: European journal of pharmacology, Vol. 882, pp. 173321, (2020) (PubMed).: "Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency." in: Nature communications, Vol. 11, Issue 1, pp. 970, (2020) (PubMed).
: "Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury." in: Journal of Korean medical science, Vol. 32, Issue 10, pp. 1616-1625, (2018) (PubMed).
: "Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury." in: The Korean journal of internal medicine, Vol. 32, Issue 6, pp. 1053-1061, (2018) (PubMed).
: "The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin." in: eLife, Vol. 4, pp. e08887, (2016) (PubMed).
: "Urinary biomarkers of chronic allograft nephropathy." in: Proteomics. Clinical applications, Vol. 9, Issue 5-6, pp. 574-85, (2015) (PubMed).
: "Urine uromodulin estimation in partial bladder outlet obstruction and cyclophosphamide-induced haemorrhagic cystitis models in rats." in: Postȩpy higieny i medycyny doświadczalnej (Online), Vol. 68, pp. 1184-92, (2015) (PubMed).
: "Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes." in: PLoS ONE, Vol. 7, Issue 12, pp. e53175, (2013) (PubMed).
: "Mass spectrometric study of stone matrix proteins of human bladder stones." in: Urology, Vol. 82, Issue 2, pp. 295-300, (2013) (PubMed).
: "Proteomic study of renal uric acid stone." in: Urology, Vol. 80, Issue 2, pp. 260-6, (2012) (PubMed).
Synonyms and alternative names related to Uromodulin
uromodulin (UMOD), uromodulin (Umod), ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP, urehr4Protein level used designations for Uromodulin
- uromodulin
- Tamm-Horsfall urinary glycoprotein
- uromucoid
- THP
- tamm-Horsfall urinary glycoprotein
- uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
- Urmodulin (Tamm-Horsfall protein)
- uromucoid, human : Tamm-Horsfall glycoprotein
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