UPF3B 抗体
(UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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UPF3B 抗体 by 适用
Find UPF3B 抗体 for a variety of species such as anti-Human UPF3B, anti-Dog UPF3B, anti-Mouse UPF3B. The species listed below are among those available. Click on a link to go to the corresponding products.
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Find UPF3B 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.
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UPF3B 抗体 by 标记
Find UPF3B 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
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Validations
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Datasheet
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Quantity
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Quantity
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Datasheet
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Reactivity
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Datasheet
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Reactivity
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Quantity
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Datasheet
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Latest Publications for our UPF3B 抗体
: "Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations." in: Genome biology, Vol. 19, Issue 1, pp. 4, (2018) (PubMed).: "RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis." in: Scientific reports, Vol. 7, pp. 41517, (2017) (PubMed).
Aliases for UPF3B 抗体
UPF3B, regulator of nonsense mediated mRNA decay (UPF3B) 抗体UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b) 抗体
UPF3B, regulator of nonsense mediated mRNA decay (Upf3b) 抗体
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