UPF3B 产品
(UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
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This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured UPF3B Categories
Recommended UPF3B 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
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Validations
- (1)
- (4)
Cat. No.
ABIN3043956
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
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- (3)
Cat. No.
ABIN7167644
Quantity
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Datasheet
Datasheet
Reactivity
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- (2)
Cat. No.
ABIN203166
Quantity
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Datasheet
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Recommended UPF3B ELISA试剂盒
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Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
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Validations
Cat. No.
ABIN6234778
Quantity
96 tests
Datasheet
Datasheet
Recommended UPF3B 蛋白
Product
Reactivity
Source
Validations
Cat. No.
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Datasheet
Reactivity
Human
Source
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Validations
- (1)
Cat. No.
ABIN2735037
Quantity
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Datasheet
Datasheet
Latest Publications for our UPF3B Products
: "Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations." in: Genome biology, Vol. 19, Issue 1, pp. 4, (2018) (PubMed).: "RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis." in: Scientific reports, Vol. 7, pp. 41517, (2017) (PubMed).
Synonyms and alternative names related to UPF3B
UPF3B, regulator of nonsense mediated mRNA decay (UPF3B), UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), UPF3B, regulator of nonsense mediated mRNA decay (Upf3b), 5730594O13Rik, AI317193, AW541158, HUPF3B, MRXS14, RENT3B, RGD1560264, UPF3XProtein level used designations for UPF3B
- hUpf3p-X
- nonsense mRNA reducing factor 3B
- regulator of nonsense transcripts 3B
- up-frameshift suppressor 3 homolog B
- up-frameshift suppressor 3 homolog on chromosome X
- hUPF3B
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