UNC13B 产品
(Unc-13 Homolog B (UNC13B))
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This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008].
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UNC13B 抗体
High quality antibodies with extensive validation data.
Recommended UNC13B 抗体
Product
Reactivity
Application
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Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7166241
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (3)
Cat. No.
ABIN7271215
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (3)
Cat. No.
ABIN2856793
Quantity
100 μL
Datasheet
Datasheet
Recommended UNC13B 蛋白
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Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324644
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our UNC13B Products
: "CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis." in: Molecular biology of the cell, Vol. 25, Issue 4, pp. 508-21, (2014) (PubMed).: "Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 50, pp. 20485-90, (2012) (PubMed).
: "Early steps in the assembly of photoreceptor ribbon synapses in the mouse retina: the involvement of precursor spheres." in: The Journal of comparative neurology, Vol. 512, Issue 6, pp. 814-24, (2008) (PubMed).
: "Detection of novel amplicons in prostate cancer by comprehensive genomic profiling of prostate cancer cell lines using oligonucleotide-based arrayCGH." in: PLoS ONE, Vol. 2, Issue 8, pp. e769, (2007) (PubMed).
: "Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release." in: Neuron, Vol. 21, Issue 1, pp. 123-36, (1998) (PubMed).
: "A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13." in: Biochemical and biophysical research communications, Vol. 248, Issue 3, pp. 846-51, (1998) (PubMed).
: "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery." in: The Journal of biological chemistry, Vol. 272, Issue 26, pp. 16081-4, (1997) (PubMed).
: "Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins." in: The Journal of biological chemistry, Vol. 270, Issue 42, pp. 25273-80, (1995) (PubMed).
Synonyms and alternative names related to UNC13B
unc-13 homolog B (UNC13B), unc-13 homolog B (Unc13b), unc-13 homolog B (C. elegans) (Unc13b), MUNC13, Munc13-1, Munc13-2, UNC13, Unc13a, UNC13B, Unc13h1, Unc13h2Protein level used designations for UNC13B
- homolog of rat Munc13 (diacylglycerol-binding)
- munc13-2
- protein unc-13 homolog B
- unc-13 homolog B (C. elegans)
- unc-13 B-like protein
- UNC-13 homolog 1
- munc13
- unc-13 homolog A
- unc13 homolog 1
- protein unc-13 homolog B-like
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