UMPS 产品
(Uridine Monophosphate Synthetase (UMPS))
Categories
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
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Featured UMPS Categories
Recommended UMPS 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (4)
Cat. No.
ABIN521259
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7175108
Quantity
100 μg
Datasheet
Datasheet
Recommended UMPS 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324639
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324637
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2735007
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our UMPS Products
: "Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer." in: The pharmacogenomics journal, Vol. 13, Issue 2, pp. 148-58, (2013) (PubMed).: "Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside-induced apoptosis in multiple myeloma cells." in: Molecular cancer therapeutics, Vol. 12, Issue 7, pp. 1310-21, (2013) (PubMed).
: "Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study." in: European journal of cancer (Oxford, England : 1990), Vol. 45, Issue 11, pp. 1999-2006, (2009) (PubMed).
: "Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia." in: BJU international, Vol. 101, Issue 2, pp. 216-8, (2008) (PubMed).
Synonyms and alternative names related to UMPS
Orotidine 5'-phosphate decarboxylase (umps-1), uridine monophosphate synthetase (umps), uridine monophosphate synthetase L homeolog (umps.L), uridine monophosphate synthetase (UMPS), uridine 5'-monophosphate synthase (LOC100556619), uridine monophosphate synthetase (Umps), 1700095D23Rik, AA408257, AL033308, BB164745, OPRT, UMPS, zgc:55702, zgc:55723Protein level used designations for UMPS
- Uridine MonoPhosphate Synthetase family member (umps-1)
- uridine 5'-monophosphate synthase
- uridine monophosphate synthetase
- uridine monophosphate synthase
- uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)
- OMPdecase
- OPRTase
- UMP synthase
- orotate phosphoribosyltransferase
- orotidine 5'-phosphate decarboxylase
- orotate phosphoribosyl transferase and orotidine-5'-decarboxylase
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