Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator autophagy (By similarity).
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ULK3 抗体 by 抗原表位
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ULK3 抗体 by 标记
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Maloverjan, Piirsoo, Kasak, Peil, Østerlund, Kogerman: "Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway." in: The Journal of biological chemistry, Vol. 285, Issue 39, pp. 30079-90, (2010) (PubMed).
Aliases for ULK3 抗体
unc-51 like kinase 3 (ULK3) 抗体 unc-51 like kinase 3 (ulk3) 抗体 unc-51 like kinase 3 (Ulk3) 抗体 unc-51 like kinase 3 L homeolog (ulk3.L) 抗体 unc-51-like kinase 3 (Ulk3) 抗体 1200015E14Rik 抗体 zgc:162196 抗体
