UIMC1 抗体
(Ubiquitin Interaction Motif Containing 1 (UIMC1))
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B\; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly Act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity).
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UIMC1 抗体 by 抗原表位
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UIMC1 抗体 by 克隆形成能力
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UIMC1 抗体 by 克隆
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UIMC1 抗体 by 标记
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Popular UIMC1 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
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Cat. No.
ABIN7145750
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, IP
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Cat. No.
ABIN526885
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, IF
Validations
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Cat. No.
ABIN6149915
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, FACS
Validations
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Cat. No.
ABIN1944736
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IF
Validations
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Cat. No.
ABIN7263231
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN526883
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
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Cat. No.
ABIN570767
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB
Validations
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Cat. No.
ABIN7271136
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p), EIA
Validations
- (2)
Cat. No.
ABIN500569
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p), EIA
Validations
- (2)
Cat. No.
ABIN500567
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN7145753
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN7145751
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA
Validations
Cat. No.
ABIN6389424
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, IF (p)
Validations
Cat. No.
ABIN7449010
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our UIMC1 抗体
: "The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair." in: Molecular cell, Vol. 69, Issue 5, pp. 866-878.e7, (2019) (PubMed).: "Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. ..." in: The Journal of clinical investigation, Vol. 129, Issue 2, pp. 786-801, (2019) (PubMed).
: "MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites." in: Scientific reports, Vol. 8, Issue 1, pp. 10888, (2018) (PubMed).
: "Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair." in: Cell, Vol. 175, Issue 2, pp. 558-570.e11, (2018) (PubMed).
: "The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites." in: Nature communications, Vol. 8, pp. 15751, (2017) (PubMed).
: "Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells." in: Nucleic acids research, Vol. 44, Issue 2, pp. 648-56, (2016) (PubMed).
: "Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors." in: Molecular cancer research : MCR, Vol. 12, Issue 3, pp. 381-93, (2014) (PubMed).
: "Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice." in: Molecular cell, Vol. 53, Issue 4, pp. 617-30, (2014) (PubMed).
: "Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25510-9, (2012) (PubMed).
: "NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11734-45, (2011) (PubMed).
Aliases for UIMC1 抗体
ubiquitin interaction motif containing 1 (UIMC1) 抗体ubiquitin interaction motif containing 1 (Uimc1) 抗体
9430016E08Rik 抗体
D330018D10Rik 抗体
D630032M02Rik 抗体
RAP80 抗体
RGD1307009 抗体
RIP110 抗体
Rxrip110 抗体
UIMC1 抗体
X2HRIP110 抗体
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