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UGT1A1 产品

(UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008].

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Featured UGT1A1 Categories

UGT1A1 抗体

High quality antibodies with extensive validation data.

UGT1A1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

UGT1A1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended UGT1A1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (1)
  • (6)
Cat. No. ABIN6149895
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IF
Validations
  • (4)
Cat. No. ABIN7262012
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (5)
Cat. No. ABIN5693290
Quantity 100 μg
Datasheet Datasheet

Recommended UGT1A1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6960358
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6975305
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN6960359
Quantity 96 tests
Datasheet Datasheet

Recommended UGT1A1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324569
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7408798
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7404989
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our UGT1A1 Products

Lv, Feng, Ai, Hou, Wang, Zou, Cheng, Ge, Cui, Yang: "A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin." in: Journal of medicinal chemistry, Vol. 60, Issue 23, pp. 9664-9675, (2017) (PubMed).

Kim, Gallaher, Chen, Gallaher, Yao, Trudo: "Phenethyl isothiocyanate and indole-3-carbinol from cruciferous vegetables, but not furanocoumarins from apiaceous vegetables, reduced PhIP-induced DNA adducts in Wistar rats." in: Molecular nutrition & food research, Vol. 60, Issue 9, pp. 1956-66, (2016) (PubMed).

Kim, Gallaher, Chen, Yao, Trudo: "Apiaceous vegetable consumption decreases PhIP-induced DNA adducts and increases methylated PhIP metabolites in the urine metabolome in rats." in: The Journal of nutrition, Vol. 145, Issue 3, pp. 442-51, (2015) (PubMed).

Yang, He, Zhou: "Fenofibrate pre-treatment suppressed inflammation by activating phosphoinositide 3 kinase/protein kinase B (PI3K/Akt) signaling in renal ischemia-reperfusion injury." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 35, Issue 1, pp. 58-63, (2015) (PubMed).

Ding, Zhang, Zhan, Yang, Wang: "Danning tablets attenuates ?-naphthylisothiocyanate-induced cholestasis by modulating the expression of transporters and metabolic enzymes." in: BMC complementary and alternative medicine, Vol. 14, pp. 249, (2014) (PubMed).

Synonyms and alternative names related to UGT1A1

UDP glucuronosyltransferase family 1 member A1 (UGT1A1), UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1), UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1), UDP-glucuronosyltransferase 1-1 (LOC100065342), UDP-glucuronosyltransferase (LOC100125517), UDP-glucuronosyltransferase 1-1 (LOC100229734), UDP-glucuronosyltransferase 1-6 (LOC100405984), UDP-glucuronosyltransferase 1-1 (LOC100511479), UDP glucuronosyltransferase family 1 member A1 (Ugt1a1), UDP glucuronosyltransferase 1 family polypeptide a1 (ugt1a1), BILIQTL1, GNT1, Gnt1, HUG-BR1, UDPGT, Udpgt, Udpgt-1a, UDPGT 1-1, UGT1, Ugt1, UGT1A, UGT1A01, UgtBr1, zgc:123097

Protein level used designations for UGT1A1

  • UDP glycosyltransferase 1 family, polypeptide A1
  • UDP-glucuronosyltransferase 1-1
  • UDP-glucuronosyltransferase 1-A
  • UDP-glucuronosyltransferase 1A1
  • UGT-1A
  • UGT1*1
  • UGT1-01
  • UGT1.1
  • bilirubin UDP-glucuronosyltransferase 1-1
  • bilirubin UDP-glucuronosyltransferase isozyme 1
  • bilirubin-specific UDPGT isozyme 1
  • UDP-glucuronosyltransferase 1 family, member 1
  • UDP-glucuronosyltransferase 1 family, polypeptide A1
  • UDPGT
  • UDP glucuronosyltransferase 1 family, polypeptide A1
  • uridine diphosphate glucuronosyltransferase 1A1
  • UDP-glucuronosyltransferase UGT1A01
  • UDP glucuronosyltransferase 1 family polypeptide A1
  • UDP glycosyl transferase 1A1
  • UDP-glucuronosyltransferase 1-1-like
  • B1
  • UDP-glucuronosyltransferase 1 family member 1
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