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UBR2 产品

(Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))

Categories

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

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Featured UBR2 Categories

UBR2 抗体

High quality antibodies with extensive validation data.

UBR2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended UBR2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, RNAi
Validations
  • (5)
Cat. No. ABIN565040
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN6265862
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7151297
Quantity 100 μg
Datasheet Datasheet

Recommended UBR2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324470
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324472
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our UBR2 Products

Zhang, Liu, Ding, Miao, Garcia, Li: "Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways." in: Scientific reports, Vol. 7, Issue 1, pp. 2273, (2019) (PubMed).

Sin, Zhu, Zhang, Li: "p300 Mediates Muscle Wasting in Lewis Lung Carcinoma." in: Cancer research, Vol. 79, Issue 7, pp. 1331-1342, (2019) (PubMed).

Zhang, Liu, Ding, Zhou, Doan, Sin, Zhu, Flores, Wen, Gong, Liu, Li: "Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90." in: Nature communications, Vol. 8, Issue 1, pp. 589, (2018) (PubMed).

Cha-Molstad, Yu, Feng, Lee, Kim, Yang, Han, Sung, Yoo, Hwang, McGuire, Shim, Song, Ganipisetti, Wang, Jang, Lee, Kim, Lee, Hong, Ciechanover, Mook-Jung, Kim, Xie, Kwon, Kim: "p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis." in: Nature communications, Vol. 8, Issue 1, pp. 102, (2017) (PubMed).

Ding, Zhang, Sin, Liu, Lin, Li, Li: "Activin A induces skeletal muscle catabolism via p38β mitogen-activated protein kinase." in: Journal of cachexia, sarcopenia and muscle, (2016) (PubMed).

Eldeeb, Fahlman: "Phosphorylation Impacts N-end Rule Degradation of the Proteolytically Activated Form of BMX Kinase." in: The Journal of biological chemistry, Vol. 291, Issue 43, pp. 22757-22768, (2016) (PubMed).

Zhang, Lin, Kwon, Li: "Signaling mechanism of tumor cell-induced up-regulation of E3 ubiquitin ligase UBR2." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 7, pp. 2893-901, (2013) (PubMed).

Zenker, Mayerle, Lerch, Tagariello, Zerres, Durie, Beier, Hülskamp, Guzman, Rehder, Beemer, Hamel, Vanlieferinghen, Gershoni-Baruch, Vieira, Dumic, Auslender, Gil-da-Silva-Lopes, Steinlicht, Rauh et al.: "Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). ..." in: Nature genetics, Vol. 37, Issue 12, pp. 1345-50, (2005) (PubMed).

Synonyms and alternative names related to UBR2

ubiquitin protein ligase E3 component n-recognin 2 (UBR2), ubiquitin protein ligase E3 component n-recognin 2 (ubr2), ubiquitin protein ligase E3 component n-recognin 2 S homeolog (ubr2.S), ubiquitin protein ligase E3 component n-recognin 2 (Ubr2), 9930021A08Rik, AI462103, AW540746, ba49a4.1, bA49A4.1, C6orf133, dJ242G1.1, dJ392M17.3, E130209G04Rik, mKIAA0349, RP3-392M17.3, si:ch211-239i4.2

Protein level used designations for UBR2

  • ubiquitin protein ligase E3 component n-recognin 2
  • rp3-392m17.3
  • E3 ubiquitin-protein ligase UBR2
  • ubiquitin-protein ligase E3-alpha-2
  • ubiquitin-protein ligase E3-alpha-II
  • N-recognin-2
  • ubiquitin ligase E3 alpha-II
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