ube3a 产品
(Ubiquitin Protein Ligase E3A (ube3a))
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This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008].
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Featured ube3a Categories
ube3a 抗体
High quality antibodies with extensive validation data.
ube3a ELISA试剂盒
Reliable ELISA kits for a wide range of species.
ube3a 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ube3a 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (1)
- (6)
Cat. No.
ABIN563326
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (11)
Cat. No.
ABIN7076105
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), FACS
Validations
- (1)
- (4)
Cat. No.
ABIN388925
Quantity
400 μL
Datasheet
Datasheet
Recommended ube3a ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971042
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960350
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1572964
Quantity
96 tests
Datasheet
Datasheet
Recommended ube3a 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324426
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324424
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7393133
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ube3a Products
: "Cognition and Synaptic-Plasticity Related Changes in Aged Rats Supplemented with 8- and 10-Carbon Medium Chain Triglycerides." in: PLoS ONE, Vol. 11, Issue 8, pp. e0160159, (2017) (PubMed).: "A coding-independent function of an alternative Ube3a transcript during neuronal development." in: Nature neuroscience, Vol. 18, Issue 5, pp. 666-73, (2015) (PubMed).
: "A fine balance: Regulation of hippocampal Arc/Arg3.1 transcription, translation and degradation in a rat model of normal cognitive aging." in: Neurobiology of learning and memory, Vol. 115, pp. 58-67, (2014) (PubMed).
: "Interaction of HPV E6 oncoproteins with specific proteasomal subunits." in: Virology, Vol. 446, Issue 1-2, pp. 389-96, (2013) (PubMed).
: "E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis." in: Blood, Vol. 120, Issue 4, pp. 822-32, (2012) (PubMed).
: "Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a." in: Human molecular genetics, Vol. 21, Issue 13, pp. 3001-12, (2012) (PubMed).
: "Spatial and temporal silencing of the human maternal UBE3A gene." in: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, Vol. 16, Issue 6, pp. 587-91, (2012) (PubMed).
: "Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome." in: PLoS ONE, Vol. 6, Issue 12, pp. e27221, (2011) (PubMed).
: "Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 12, pp. 5611-6, (2010) (PubMed).
: "Isoform-specific degradation of PR-B by E6-AP is critical for normal mammary gland development." in: Molecular endocrinology (Baltimore, Md.), Vol. 24, Issue 11, pp. 2099-113, (2010) (PubMed).
Synonyms and alternative names related to ube3a
ubiquitin protein ligase E3A (UBE3A), ubiquitin-protein ligase E3A (ube3a), ubiquitin-protein ligase E3A (LOC100194730), ubiquitin protein ligase E3A (Ube3a), ubiquitin protein ligase E3A (ube3a), Ubiquitin protein ligase E3A (Ube3a), ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) S homeolog (ube3a.S), ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (ube3a), ubiquitin protein ligase E3A (Eint_040430), 4732496B02, 5830462N02Rik, A130086L21Rik, ANCR, AS, As, CG6190, das, DDBDRAFT_0188760, DDBDRAFT_0302447, DDB_0188760, DDB_0302447, Dmel\\CG6190, Dube3a, dUBE3A, dube3A, dube3a, E6-AP, EPVE6AP, HPVE6A, Hpve6a, im:7140733, MGC69536, mKIAA4216, ube3a, UBE3A, UME3A, zgc:92173Protein level used designations for ube3a
- CTCL tumor antigen se37-2
- E6AP ubiquitin-protein ligase
- human papilloma virus E6-associated protein
- human papillomavirus E6-associated protein
- oncogenic protein-associated protein E6-AP
- renal carcinoma antigen NY-REN-54
- ubiquitin-protein ligase E3A
- ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)
- ubiquitin protein ligase E3A
- E6-AP ubiquitin protein ligase
- ubiquitin conjugating enzyme E3A
- CG6190-PA
- Ube3a-PA
- drosophila angelman syndrome
- angelman syndrome
- ubiquitin-protein ligase E3A-like
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