UBE2D1 产品
(Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1))
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].
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Featured UBE2D1 Categories
Recommended UBE2D1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (1)
- (4)
Cat. No.
ABIN521211
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN7259985
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7174434
Quantity
100 μg
Datasheet
Datasheet
Recommended UBE2D1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951479
Quantity
96 tests
Datasheet
Datasheet
Recommended UBE2D1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125608
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324340
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324342
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our UBE2D1 Products
: "UBE2L3 polymorphism amplifies NF-?B activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases." in: American journal of human genetics, Vol. 96, Issue 2, pp. 221-34, (2015) (PubMed).: "The stability of herpes simplex virus 1 ICP0 early after infection is defined by the RING finger and the UL13 protein kinase." in: Journal of virology, Vol. 88, Issue 10, pp. 5437-43, (2014) (PubMed).
: "Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 303, Issue 6, pp. L519-27, (2012) (PubMed).
: "A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter." in: Nature cell biology, Vol. 5, Issue 8, pp. 754-61, (2003) (PubMed).
: "UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis." in: Blood, Vol. 101, Issue 8, pp. 3288-93, (2003) (PubMed).
: "Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 19, pp. 10430-5, (2000) (PubMed).
Synonyms and alternative names related to UBE2D1
ubiquitin conjugating enzyme E2 D1 (UBE2D1), ubiquitin-conjugating enzyme E2D 1 (Ube2d1), ubiquitin-conjugating enzyme E2D 1b (ube2d1b), ubiquitin conjugating enzyme E2 D1 S homeolog (ube2d1.S), ubiquitin conjugating enzyme E2 D1 (ube2d1), ubiquitin conjugating enzyme E2 D1 (Ube2d1), E2(17)KB1, e2(17)kb1, SFT, sft, UBC4/5, ubc4/5, UBCH5, ubch5, UBCH5A, ubch5a, ube2d1, wu:fc16h06, zgc:73096Protein level used designations for UBE2D1
- UBC4/5 homolog
- stimulator of Fe transport
- ubiquitin carrier protein D1
- ubiquitin-conjugating enzyme E2 D1
- ubiquitin-conjugating enzyme E2(17)KB 1
- ubiquitin-conjugating enzyme E2-17 kDa 1
- ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)
- ubiquitin-protein ligase D1
- E2(17)KB 1
- ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog
- ubiquitin-conjugating enzyme E2D 1
- ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog)
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