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UBA3 产品

(Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured UBA3 Categories

UBA3 抗体

High quality antibodies with extensive validation data.

UBA3 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

UBA3 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended UBA3 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (4)
Cat. No. ABIN387909
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA
Validations
  • (2)
Cat. No. ABIN6265835
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN7271186
Quantity 100 μL
Datasheet Datasheet

Recommended UBA3 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6971051
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1144447
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1144448
Quantity 96 tests
Datasheet Datasheet

Recommended UBA3 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324294
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125641
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7422043
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our UBA3 Products

Xie, Zhang, He, Lu, Chen, Xing, Lu, Liu, Li, Wang, Chai, Wu, Deng, Wang, Cao, Zhao, Cui, Wang, He, Zhang: "The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis." in: Nature communications, Vol. 5, pp. 3733, (2014) (PubMed).

Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).

Walden, Podgorski, Schulman: "Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8." in: Nature, Vol. 422, Issue 6929, pp. 330-4, (2003) (PubMed).

Bohnsack, Haas: "Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer." in: The Journal of biological chemistry, Vol. 278, Issue 29, pp. 26823-30, (2003) (PubMed).

Synonyms and alternative names related to UBA3

ubiquitin like modifier activating enzyme 3 (UBA3), ubiquitin-like modifier activating enzyme 3 (Uba3), ubiquitin-like modifier activating enzyme 3 (uba3), ubiquitin like modifier activating enzyme 3 (uba3), ubiquitin like modifier activating enzyme 3 S homeolog (uba3.S), A830034N06Rik, AI256736, AI848246, AW546539, hUBA3, UBE1C, Ube1c, ube1c, wu:fb75e04, wu:fc37b11, zgc:55528

Protein level used designations for UBA3

  • NEDD8-activating enzyme E1 catalytic subunit
  • NEDD8-activating enzyme E1C
  • Nedd8-activating enzyme hUba3
  • UBA3, ubiquitin-activating enzyme E1 homolog
  • ubiquitin-activating enzyme 3
  • ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)
  • ubiquitin-activating enzyme E1C (homologous to yeast UBA3)
  • ubiquitin-like modifier-activating enzyme 3
  • ubiquitin activating enzyme 3
  • ubiquitin-activating enzyme E1C
  • ubiquitin-like modifier activating enzyme 3
  • NEDD8-activating enzyme E1 catalytic subunit-like
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