TYROBP 产品
(TYRO Protein tyrosine Kinase Binding Protein (TYROBP))
Categories
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010].
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Featured TYROBP Categories
TYROBP 抗体
High quality antibodies with extensive validation data.
TYROBP ELISA试剂盒
Reliable ELISA kits for a wide range of species.
TYROBP 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TYROBP 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse, Rat
Application
IHC
Validations
- (2)
Cat. No.
ABIN7261337
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (2)
Cat. No.
ABIN6265826
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN653819
Quantity
400 μL
Datasheet
Datasheet
Recommended TYROBP ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971010
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960320
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Validations
Cat. No.
ABIN1164547
Quantity
96 tests
Datasheet
Datasheet
Recommended TYROBP 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324265
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324267
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7414999
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our TYROBP Products
: "Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome." in: Journal of neuroinflammation, Vol. 16, Issue 1, pp. 63, (2019) (PubMed).: "The female reproductive tract contains multiple innate sialic acid-binding immunoglobulin-like lectins (Siglecs) that facilitate sperm survival." in: The Journal of biological chemistry, Vol. 294, Issue 31, pp. 11910-11919, (2019) (PubMed).
: "CD33 modulates TREM2: convergence of Alzheimer loci." in: Nature neuroscience, Vol. 18, Issue 11, pp. 1556-8, (2016) (PubMed).
: "Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis." in: Neuropathology and applied neurobiology, Vol. 41, Issue 7, pp. 952-63, (2015) (PubMed).
: "DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells." in: Journal of leukocyte biology, Vol. 94, Issue 2, pp. 301-13, (2013) (PubMed).
: "The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function." in: Immunology today, Vol. 21, Issue 12, pp. 611-4, (2001) (PubMed).
: "Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts." in: Nature genetics, Vol. 25, Issue 3, pp. 357-61, (2000) (PubMed).
: "Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice." in: Immunity, Vol. 13, Issue 3, pp. 355-64, (2000) (PubMed).
Synonyms and alternative names related to TYROBP
TYRO protein tyrosine kinase binding protein (TYROBP), TYRO protein tyrosine kinase binding protein (tyrobp), Tyro protein tyrosine kinase binding protein (Tyrobp), TYRO protein tyrosine kinase binding protein (Tyrobp), DAP12, dap12, Karap, KARAP, Ly83, PLOSL, TYROBP, tyrpbpProtein level used designations for TYROBP
- TYRO protein tyrosine kinase-binding protein
- TYRO protein tyrosine kinase binding protein
- DAP12 protein
- dap12
- DAP12
- DNAX-activation protein 12
- killer cell activating receptor-associated protein
- KAR-associated protein
- killer activating receptor associated protein
- killer-activating receptor-associated protein
- killer cell activating receptor associated protein
- immunoreceptor DAP12
- tyrosine kinase binding protein
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