TYK2 产品
(Tyrosine Kinase 2 (TYK2))
Categories
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008].
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Featured TYK2 Categories
TYK2 抗体
High quality antibodies with extensive validation data.
TYK2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
TYK2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TYK2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p), IP
Validations
- (7)
Cat. No.
ABIN563303
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (6)
Cat. No.
ABIN521186
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (6)
Cat. No.
ABIN3022988
Quantity
100 μL
Datasheet
Datasheet
Recommended TYK2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
Cat. No.
ABIN1981732
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971021
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960329
Quantity
96 tests
Datasheet
Datasheet
Recommended TYK2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324253
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509189
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7394390
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our TYK2 Products
: "Proteome-wide epitope mapping of antibodies using ultra-dense peptide arrays." in: Molecular & cellular proteomics : MCP, Vol. 13, Issue 6, pp. 1585-97, (2014) (PubMed).: "TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia." in: Cancer discovery, Vol. 3, Issue 5, pp. 564-77, (2013) (PubMed).
: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, (2006) (PubMed).
: "Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography." in: Molecular & cellular proteomics : MCP, Vol. 4, Issue 6, pp. 721-30, (2005) (PubMed).
: "TYK2 is a key regulator of the surveillance of B lymphoid tumors." in: The Journal of clinical investigation, Vol. 114, Issue 11, pp. 1650-8, (2004) (PubMed).
: "Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1077-83, (2003) (PubMed).
: "The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression." in: The EMBO journal, Vol. 22, Issue 3, pp. 537-47, (2003) (PubMed).
: "Urokinase-induced migration of human vascular smooth muscle cells requires coupling of the small GTPases RhoA and Rac1 to the Tyk2/PI3-K signalling pathway." in: Thrombosis and haemostasis, Vol. 89, Issue 5, pp. 904-14, (2003) (PubMed).
: "Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 7, pp. 3794-800, (2003) (PubMed).
: "Regulation of STAT protein synthesis by c-Cbl." in: Oncogene, Vol. 20, Issue 50, pp. 7326-33, (2001) (PubMed).
Synonyms and alternative names related to TYK2
tyrosine kinase 2 (TYK2), tyrosine kinase 2 (Tyk2), JTK1Protein level used designations for TYK2
- non-receptor tyrosine-protein kinase TYK2
- tyrosine kinase TYK2
- non-receptor tyrosine kinase Tyk2
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