Tumor Necrosis Factor (Ligand) Superfamily, Member 11 产品
(Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
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This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008].
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Featured Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Categories
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 抗体
High quality antibodies with extensive validation data.
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Tumor Necrosis Factor (Ligand) Superfamily, Member 11 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rabbit, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (12)
- (6)
Cat. No.
ABIN668556
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (1)
- (8)
Cat. No.
ABIN5611143
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC (p), IF
Validations
- (6)
Cat. No.
ABIN7210648
Quantity
100 μL
Datasheet
Datasheet
Recommended Tumor Necrosis Factor (Ligand) Superfamily, Member 11 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (11)
- (5)
Cat. No.
ABIN6574228
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (9)
- (1)
Cat. No.
ABIN6960248
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6960249
Quantity
96 tests
Datasheet
Datasheet
Recommended Tumor Necrosis Factor (Ligand) Superfamily, Member 11 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275517
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275516
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275518
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Products
: "Bone Remodeling in Mandible of Wistar Rats with Diabetes Mellitus and Osteoporosis." in: European journal of dentistry, (2022) (PubMed).: "Differential Expression of Dickkopf 1 and Periostin in Mouse Strains with High and Low Bone Mass." in: Biology, Vol. 11, Issue 12, (2022) (PubMed).
: "Comparison of RANKL expression, inflammatory markers, and cardiovascular risk in patients with acute coronary syndrome with and without rheumatoid arthritis." in: Rheumatology international, Vol. 39, Issue 10, pp. 1723-1732, (2020) (PubMed).
: "Mice lacking plastin-3 display a specific defect of cortical bone acquisition." in: Bone, Vol. 130, pp. 115062, (2020) (PubMed).
: "RANKL-mediated osteoclastogenic differentiation of macrophages in the abdominal aorta of angiotensin II-infused apolipoprotein E knockout mice." in: Journal of vascular surgery, Vol. 68, Issue 6S, pp. 48S-59S.e1, (2019) (PubMed).
: "The impact of forced swimming on expression of RANKL and OPG in a type 2 diabetes mellitus rat model." in: Archives of physiology and biochemistry, Vol. 125, Issue 3, pp. 195-200, (2019) (PubMed).
: "Role of interleukin-33 in the clinical pathogenesis of chronic apical periodontitis." in: The Journal of international medical research, Vol. 47, Issue 7, pp. 3332-3343, (2019) (PubMed).
: "Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain." in: Mediators of inflammation, Vol. 2019, pp. 2514956, (2019) (PubMed).
: "The role of mechanotransduction versus hypoxia during simulated orthodontic compressive strain-an in vitro study of human periodontal ligament fibroblasts." in: International journal of oral science, Vol. 11, Issue 4, pp. 33, (2019) (PubMed).
: "The Role of MicroRNA-143-5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting Runx2 via the OPG/RANKL Signaling Pathway." in: Journal of cellular biochemistry, Vol. 119, Issue 1, pp. 536-546, (2018) (PubMed).
Synonyms and alternative names related to Tumor Necrosis Factor (Ligand) Superfamily, Member 11
TNF superfamily member 11 (TNFSF11), tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11), TNF superfamily member 11 (Tnfsf11), TNF receptor superfamily member 11b (TNFRSF11B), TNF superfamily member 11 L homeolog (tnfsf11.L), CD254, cd254, hRANKL2, Ly109l, ODF, odf, OPG, OPGL, opgl, OPTB2, optb2, RANKL, rankl, sOdf, sodf, TNFSF11, tnfsf11, TRANCE, Trance, tranceProtein level used designations for Tumor Necrosis Factor (Ligand) Superfamily, Member 11
- TNF-related activation-induced cytokine
- osteoclast differentiation factor
- osteoprotegerin ligand
- receptor activator of nuclear factor kappa B ligand
- receptor activator of nuclear factor kappa-B ligand
- tumor necrosis factor ligand superfamily member 11
- tumor necrosis factor (ligand) superfamily, member 11
- Receptor activator of nuclear factor kappa-B ligand
- OPG ligand
- receptor activator of NF-kappaB ligand
- tumor necrosis factor-related activation-induced cytokine
- ODF
- OPGL
- TRANCE
- osteoprotegerin
- TNF superfamily member 11 L homeolog
- tumor necrosis factor superfamily member 11 L homeolog
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