TRPM8 产品
(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
Categories
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
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Featured TRPM8 Categories
TRPM8 抗体
High quality antibodies with extensive validation data.
TRPM8 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
TRPM8 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TRPM8 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (5)
Cat. No.
ABIN392821
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (5)
Cat. No.
ABIN3029240
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (5)
Cat. No.
ABIN3029242
Quantity
0.4 mL
Datasheet
Datasheet
Recommended TRPM8 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960128
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5659487
Quantity
96 tests
Datasheet
Datasheet
Recommended TRPM8 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7413904
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3116017
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3136669
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our TRPM8 Products
: "TRPM8 thermosensation in poikilotherms mediates both skin colour and locomotor performance responses to cold temperature." in: Communications biology, Vol. 6, Issue 1, pp. 127, (2023) (PubMed).: "TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells." in: Cancers, Vol. 14, Issue 9, (2022) (PubMed).
: "Gpr83 Tunes Nociceptor Function, Controlling Pain." in: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, (2022) (PubMed).
: "TRPM8 as an Anti-Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination." in: International journal of molecular sciences, Vol. 23, Issue 12, (2022) (PubMed).
: "Testosterone-androgen receptor: The steroid link inhibiting TRPM8-mediated cold sensitivity." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 6, pp. 7483-7499, (2021) (PubMed).
: "TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration." in: Cell death & disease, Vol. 10, Issue 9, pp. 652, (2020) (PubMed).
: "Activation of Transient Receptor Potential Melastatin Subtype 8 Attenuates Cold-Induced Hypertension Through Ameliorating Vascular Mitochondrial Dysfunction." in: Journal of the American Heart Association, Vol. 6, Issue 8, (2018) (PubMed).
: "TRPM8 in the negative regulation of TNFα expression during cold stress." in: Scientific reports, Vol. 7, pp. 45155, (2017) (PubMed).
: "TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1." in: The Journal of cell biology, Vol. 216, Issue 7, pp. 2107-2130, (2017) (PubMed).
: "Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation." in: PLoS ONE, Vol. 9, Issue 9, pp. e107151, (2015) (PubMed).
Synonyms and alternative names related to TRPM8
transient receptor potential cation channel subfamily M member 8 (TRPM8), transient receptor potential cation channel subfamily M member 8b L homeolog (trpm8b.L), transient receptor potential cation channel subfamily M member 8 (Trpm8), transient receptor potential cation channel, subfamily M, member 8 (Trpm8), transient receptor potential cation channel, subfamily M, member 8 (TRPM8), CMR1, LTrpC-6, ltrpc6, LTRPC6, Trp-p8, TRPM8, trpm8b, trpp8, TRPP8Protein level used designations for TRPM8
- transient receptor potential cation channel, subfamily M, member 8
- transient receptor potential cation channel subfamily M member 8b
- transient receptor potential cation channel subfamily M member 8
- transient potential cation channel subfamily M member 8
- LTrpC-6
- long transient receptor potential channel 6
- short form of the TRPM8 cationic channel
- transient receptor potential p8
- transient receptor potential subfamily M member 8
- trp-p8
- TRP ion channel TRPM8
- transient receptor potential-p8
- cold menthol receptor 1
- cold/menthol receptor 1
- menthol receptor
- transient receptor potential M8 protein
- transient receptor potential cation channel, subfamily M, member 8 (predicted), 3 prime
- transient receptor potential cation channel, subfamily M, member 8 (predicted), 5 prime
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