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TREX1 产品

(three Prime Repair Exonuclease 1 (TREX1))

Categories

This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012].

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Featured TREX1 Categories

TREX1 抗体

High quality antibodies with extensive validation data.

TREX1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TREX1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB
Validations
  • (2)
  • (8)
Cat. No. ABIN524703
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IP
Validations
  • (3)
Cat. No. ABIN7172071
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN6149486
Quantity 100 μL
Datasheet Datasheet

Recommended TREX1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970621
Quantity 96 tests
Datasheet Datasheet

Recommended TREX1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323580
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323578
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7419013
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our TREX1 Products

Takahashi, Loo, Okada, Kamachi, Watanabe, Wakita, Watanabe, Kawamoto, Miyata, Barber, Ohtani, Hara: "Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells." in: Nature communications, Vol. 9, Issue 1, pp. 1249, (2018) (PubMed).

Sakai, Miyazaki, Shin, Kim, Qi, Fariss, Munasinghe, Wang, Kovalchuk, Kothari, Fermaintt, Atkinson, Perrino, Yan, Morse: "DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice." in: Journal of autoimmunity, Vol. 81, pp. 13-23, (2017) (PubMed).

Tomicic, Aasland, Nikolova, Kaina, Christmann: "Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs." in: Biochimica et biophysica acta, Vol. 1833, Issue 8, pp. 1832-43, (2013) (PubMed).

Christmann, Tomicic, Aasland, Berdelle, Kaina: "Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage." in: Nucleic acids research, Vol. 38, Issue 19, pp. 6418-32, (2010) (PubMed).

Höss, Robins, Naven, Pappin, Sgouros, Lindahl: "A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein." in: The EMBO journal, Vol. 18, Issue 13, pp. 3868-75, (1999) (PubMed).

Mazur, Perrino: "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 19655-60, (1999) (PubMed).

Synonyms and alternative names related to TREX1

three prime repair exonuclease 1 (CpipJ_CPIJ012074), three prime repair exonuclease 1 (Tsp_03749), three prime repair exonuclease 1 (TREX1), three prime repair exonuclease 1 (Trex1), 1661, AGS1, AU041952, CRV, DRN3, HERNS, RGD1309596

Protein level used designations for TREX1

  • three prime repair exonuclease 1
  • 3' repair exonuclease 1
  • 3'-5' exonuclease TREX1
  • DNase III
  • deoxyribonuclease III
  • three prime exonuclease 1
  • trophoblast expressed 1
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