TRAF2 抗体
(TNF Receptor-Associated Factor 2 (TRAF2))
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008].
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recommended
Verified TRAF2 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
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Latest Publications for our TRAF2 抗体
: "Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia." in: Journal of cellular and molecular medicine, Vol. 22, Issue 3, pp. 1614-1626, (2018) (PubMed).: "MicroRNA-17 Suppresses TNF-α Signaling by Interfering with TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 6, pp. 2219-28, (2017) (PubMed).
: "Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity." in: PLoS ONE, Vol. 8, Issue 1, pp. e53676, (2013) (PubMed).
: "Gsdma3 is a new factor needed for TNF-?-mediated apoptosis signal pathway in mouse skin keratinocytes." in: Histochemistry and cell biology, Vol. 138, Issue 3, pp. 385-96, (2012) (PubMed).
: "A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma." in: Oncotarget, Vol. 2, Issue 12, pp. 1055-74, (2012) (PubMed).
: "A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species." in: The Prostate, Vol. 70, Issue 10, pp. 1074-86, (2010) (PubMed).
: "Expression of TNF-receptor associated factor 2 correlates with poor progression-free survival time in ABC-like primary nodal diffuse large B-cell lymphomas." in: Histopathology, Vol. 52, Issue 5, pp. 578-84, (2008) (PubMed).
: "Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation." in: The Journal of biological chemistry, Vol. 282, Issue 21, pp. 15349-56, (2007) (PubMed).
: "TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: a novel pathway in B cell activation." in: Molecular immunology, Vol. 45, Issue 1, pp. 76-86, (2007) (PubMed).
: "Unique signaling properties of CTAR1 in LMP1-mediated transformation." in: Journal of virology, Vol. 81, Issue 18, pp. 9680-92, (2007) (PubMed).
Aliases for TRAF2 抗体
TNF-receptor-associated factor 2 (LOC661716) 抗体conjugal transfer protein TraF (traF2) 抗体
TNF receptor associated factor 2 (TRAF2) 抗体
TNF receptor-associated factor 2 (Traf2) 抗体
Tnf receptor-associated factor 2 (Traf2) 抗体
AI325259 抗体
MGC:45012 抗体
TANK 抗体
TRAP 抗体
TRAP3 抗体
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