TOP2B 抗体
(Topoisomerase (DNA) II beta 180kDa (TOP2B))
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants\; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008].
recommended
recommended
TOP2B 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
recommended
TOP2B 抗体 by 适用
Find TOP2B 抗体 for a variety of species such as anti-Human TOP2B, anti-Rat TOP2B, anti-Mouse TOP2B. The species listed below are among those available. Click on a link to go to the corresponding products.
TOP2B 抗体 by 抗体来源
Find TOP2B 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
TOP2B 抗体 by 抗原表位
Find TOP2B 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.
TOP2B 抗体 by 克隆形成能力
Find available monoclonal or polyclonal TOP2B 抗体. Click on a link to go to the corresponding products.
Popular TOP2B 抗体
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Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
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Cat. No.
ABIN7440122
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, ELISA, IF, ICC
Validations
- (3)
Cat. No.
ABIN6265674
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, IF, IP, IHC (p), ICC
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- (3)
Cat. No.
ABIN2855447
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
IHC, ELISA, IF
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- (2)
Cat. No.
ABIN7150346
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Dog, Human, Monkey, Pig
Application
WB, IHC, IF, IC
Validations
- (3)
Cat. No.
ABIN7297182
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN563225
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA
Validations
- (1)
Cat. No.
ABIN791099
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Bat, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application
WB
Validations
- (1)
Cat. No.
ABIN6742341
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application
WB
Validations
- (1)
Cat. No.
ABIN6742741
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB
Validations
- (1)
Cat. No.
ABIN927425
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB
Validations
- (2)
Cat. No.
ABIN2780351
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, ELISA
Validations
- (2)
Cat. No.
ABIN1533446
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro)
Validations
Cat. No.
ABIN6989203
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN6982644
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
IF (cc), IF (p)
Validations
Cat. No.
ABIN6976664
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our TOP2B 抗体
: "HSF1 mediated TNF-α production during proteotoxic stress response pioneers proinflammatory signal in human cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 2, pp. 2621-2635, (2019) (PubMed).: "TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency." in: Molecular cell, Vol. 74, Issue 3, pp. 466-480.e4, (2019) (PubMed).
: "Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 22, Issue 13, pp. 3310-9, (2016) (PubMed).
: "Uncovering Hidden Layers of Cell Cycle Regulation through Integrative Multi-omic Analysis." in: PLoS genetics, Vol. 11, Issue 10, pp. e1005554, (2015) (PubMed).
: "Chromatin context and ncRNA highlight targets of MeCP2 in brain." in: RNA biology, Vol. 10, Issue 11, pp. 1741-57, (2014) (PubMed).
: "Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia." in: British journal of haematology, Vol. 152, Issue 1, pp. 61-71, (2010) (PubMed).
: "Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 57, Issue 11, pp. 1013-23, (2009) (PubMed).
: "Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 5, pp. 2544-53, (2002) (PubMed).
: "Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia." in: Oncogene, Vol. 20, Issue 41, pp. 5779-88, (2001) (PubMed).
: "Immunohistochemical staining for DNA topoisomerase IIa in Hodgkin's disease." in: American journal of clinical pathology, Vol. 109, Issue 1, pp. 39-44, (1998) (PubMed).
Aliases for TOP2B 抗体
DNA topoisomerase II beta (TOP2B) 抗体topoisomerase (DNA) II beta (Top2b) 抗体
DNA topoisomerase II beta (Top2b) 抗体
microRNA 4442 (MIR4442) 抗体
D230016L12Rik 抗体
Top-2 抗体
TOP2B 抗体
top2beta 抗体
TOPIIB 抗体
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