TIRAP 产品
(Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))
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The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described. [provided by RefSeq, Jul 2008].
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Featured TIRAP Categories
TIRAP 抗体
High quality antibodies with extensive validation data.
TIRAP ELISA试剂盒
Reliable ELISA kits for a wide range of species.
TIRAP 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TIRAP 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IHC (fro), ICC
Validations
- (8)
Cat. No.
ABIN7441712
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (5)
Cat. No.
ABIN6149192
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7172290
Quantity
100 μL
Datasheet
Datasheet
Recommended TIRAP ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970732
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960023
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6223712
Quantity
96 tests
Datasheet
Datasheet
Recommended TIRAP 蛋白
Latest Publications for our TIRAP Products
: "Proximity Ligation Assays for In Situ Detection of Innate Immune Activation: Focus on In Vitro-Transcribed mRNA." in: Molecular therapy. Nucleic acids, Vol. 14, pp. 52-66, (2019) (PubMed).: "Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes." in: Frontiers in molecular neuroscience, Vol. 10, pp. 409, (2017) (PubMed).
: "Heterodimer-specific TLR2 stimulation results in divergent functional outcomes in B-cell precursor acute lymphoblastic leukemia." in: European journal of immunology, Vol. 45, Issue 7, pp. 1980-90, (2015) (PubMed).
: "Chemoprevention Activity of Dipyridamole in the MMTV-PyMT Transgenic Mouse Model of Breast Cancer." in: Cancer prevention research (Philadelphia, Pa.), Vol. 6, Issue 5, pp. 437-47, (2013) (PubMed).
: "Phosphatidylinositol 4-phosphate 5-kinase ? facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein ..." in: The Journal of biological chemistry, Vol. 288, Issue 8, pp. 5645-59, (2013) (PubMed).
: "Preferential expression and function of Toll-like receptor 3 in human astrocytes." in: Journal of neuroimmunology, Vol. 159, Issue 1-2, pp. 12-9, (2005) (PubMed).
: "Advantages and disadvantages of cytidine deamination." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 11, pp. 6513-8, (2004) (PubMed).
: "Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP." in: Blood, Vol. 103, Issue 6, pp. 2229-37, (2004) (PubMed).
: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, (2004) (PubMed).
: "The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction." in: Molecular immunology, Vol. 41, Issue 6-7, pp. 577-82, (2004) (PubMed).
Synonyms and alternative names related to TIRAP
toll-interleukin 1 receptor (TIR) domain containing adaptor protein (tirap), TIR domain containing adaptor protein (TIRAP), toll-interleukin 1 receptor (TIR) domain containing adaptor protein L homeolog (tirap.L), TIR domain containing adaptor protein (Tirap), toll-interleukin 1 receptor (TIR) domain-containing adaptor protein (Tirap), AA407980, BACTS1, C130027E04Rik, mal, Mal, MyD88-2, Tlr4ap, wyatt, WyattProtein level used designations for TIRAP
- MyD88 adapter-like protein
- Toll-interleukin 1 receptor domain-containing adaptor protein
- toll/interleukin-1 receptor domain-containing adapter protein
- TIR domain-containing adaptor protein
- Toll-like receptor adaptor protein
- adapter protein wyatt
- adaptor protein Wyatt
- toll-interleukin 1 receptor domain-containing adaptor protein
- TIR domain-containing adapter protein
- Toll-like receptor 4 adaptor protein
- myD88 adapter-like protein
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