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TIE1 产品

(tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].

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Featured TIE1 Categories

TIE1 抗体

High quality antibodies with extensive validation data.

TIE1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

TIE1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TIE1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (6)
Cat. No. ABIN2683015
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
  • (4)
Cat. No. ABIN7442504
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
  • (3)
Cat. No. ABIN7431122
Quantity 100 μL
Datasheet Datasheet

Recommended TIE1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (6)
Cat. No. ABIN6730883
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960330
Quantity 96 tests
Datasheet Datasheet
Reactivity Zebrafish (Danio rerio)
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1572722
Quantity 96 tests
Datasheet Datasheet

Recommended TIE1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
Cat. No. ABIN1589958
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN1589962
Quantity 20 μg
Datasheet Datasheet
Reactivity Mouse
Source CHO Cells
Validations
Cat. No. ABIN1589960
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our TIE1 Products

Leppänen, Saharinen, Alitalo: "Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 17, pp. 4376-4381, (2017) (PubMed).

Morooka, Futaki, Sato-Nishiuchi, Nishino, Totani, Shimono, Nakano, Nakajima, Mochizuki, Sekiguchi: "Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling." in: Circulation research, Vol. 120, Issue 8, pp. 1276-1288, (2017) (PubMed).

Hakanpaa, Sipila, Leppanen, Gautam, Nurmi, Jacquemet, Eklund, Ivaska, Alitalo, Saharinen: "Endothelial destabilization by angiopoietin-2 via integrin β1 activation." in: Nature communications, Vol. 6, pp. 5962, (2015) (PubMed).

Saulle, Guerriero, Petronelli, Coppotelli, Gabbianelli, Morsilli, Spinello, Pelosi, Castelli, Testa, Coppola: "Autocrine role of angiopoietins during megakaryocytic differentiation." in: PLoS ONE, Vol. 7, Issue 7, pp. e39796, (2012) (PubMed).

Marron, Singh, Tahir, Kavumkal, Kim, Koh, Brindle: "Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2." in: The Journal of biological chemistry, Vol. 282, Issue 42, pp. 30509-17, (2007) (PubMed).

Kim, Shin, Kim, Choi, Byun, Jeon, Suh, Kim: "Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells." in: Cardiovascular research, Vol. 72, Issue 3, pp. 394-402, (2006) (PubMed).

Lin, Lee, Sun: "Functions of the activation loop in Csk protein-tyrosine kinase." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 24072-7, (2003) (PubMed).

Huang, Chen, Inoue, Chen: "Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 9, pp. 4767-75, (2003) (PubMed).

Natarajan, Rajala, Chodosh: "Corneal IL-8 expression following adenovirus infection is mediated by c-Src activation in human corneal fibroblasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 6234-43, (2003) (PubMed).

Danet, Pan, Luongo, Bonnet, Simon: "Expansion of human SCID-repopulating cells under hypoxic conditions." in: The Journal of clinical investigation, Vol. 112, Issue 1, pp. 126-35, (2003) (PubMed).

Synonyms and alternative names related to TIE1

tyrosine kinase with immunoglobulin like and EGF like domains 1 (TIE1), tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (Tie1), tyrosine-protein kinase receptor Tie-1 (CpipJ_CPIJ018933), endothelium-specific receptor tyrosine kinase 1 (tie1), D430008P04Rik, JTK14, TIE, tie-1

Protein level used designations for TIE1

  • tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
  • tyrosine-protein kinase receptor Tie-1
  • tyrosine kinase receptor 1
  • tyrosine kinase with immunoglobulin and epidermal growth factor homology domains
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