TGIF1 产品
(TGFB-Induced Factor Homeobox 1 (TGIF1))
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The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described. [provided by RefSeq, Jul 2008].
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Recommended TGIF1 抗体
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Latest Publications for our TGIF1 Products
: "Assessment of TGIF as a candidate gene for myopia." in: Investigative ophthalmology & visual science, Vol. 49, Issue 1, pp. 49-54, (2008) (PubMed).: "A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephaly." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 21, Issue 2, pp. 488-96, (2007) (PubMed).
: "TGFB-induced factor (TGIF): a candidate gene for psychosis on chromosome 18p." in: Molecular psychiatry, Vol. 12, Issue 11, pp. 1033-41, (2007) (PubMed).
Synonyms and alternative names related to TGIF1
TGFB induced factor homeobox 1 (TGIF1), TGFB-induced factor homeobox 1 (Tgif1), TGFB-induced factor homeobox 1 (tgif1), TGFB induced factor homeobox 1 (tgif1), TGFB induced factor homeobox 1 S homeolog (tgif1.S), AA959811, AI462167, fa06h05, fb33g11, HPE4, hpe4, Tfig, TGIF, Tgif, tgif, tgif1, wu:fa06h05, wu:fb33g11, zgc:55852Protein level used designations for TGIF1
- 5'-TG-3'-interacting factor 1
- TALE homeobox TG-interacting factor
- homeobox protein TGIF1
- transforming growth factor-beta-induced factor
- TALE family homeobox
- TG interacting factor 1
- TG interacting factor
- TGFB-induced factor (TALE family homeobox)
- avian knotted-related protein
- homeobox protein AKR
- homeodomain protein AKR
- TG-interacting factor
- TGFB-induced factor homeobox 1
- TG-interacting homeobox protein
- TGFB induced factor homeobox 1 S homeolog
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