TFEB 抗体
(Transcription Factor EB (TFEB))
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
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Popular TFEB 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (5)
Cat. No.
ABIN563503
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Goat, Horse, Human, Rabbit
Application
WB
Validations
- (5)
Cat. No.
ABIN2787554
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7172536
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IHC
Validations
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Cat. No.
ABIN7172534
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN3187234
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), EIA
Validations
- (3)
Cat. No.
ABIN1450147
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Validations
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Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
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Cat. No.
ABIN563502
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Goat, Horse, Human, Monkey, Rabbit
Application
WB
Validations
- (1)
Cat. No.
ABIN6745235
Quantity
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Datasheet
Datasheet
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Application
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Cat. No.
ABIN6736030
Quantity
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Reactivity
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Application
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Cat. No.
ABIN791477
Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
ABIN931190
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Saccharomyces cerevisiae, Sheep, Zebrafish (Danio rerio)
Application
WB
Validations
- (2)
Cat. No.
ABIN2780786
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB
Validations
- (2)
Cat. No.
ABIN2792593
Quantity
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Datasheet
Datasheet
Latest Publications for our TFEB 抗体
: "Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR." in: Autophagy, Vol. 15, Issue 6, pp. 998-1016, (2019) (PubMed).: "MITA modulated autophagy flux promotes cell death in breast cancer cells." in: Cellular signalling, Vol. 35, pp. 73-83, (2018) (PubMed).
: "Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation." in: Stem cell reports, Vol. 9, Issue 6, pp. 1853-1867, (2017) (PubMed).
: "TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1." in: The international journal of biochemistry & cell biology, Vol. 78, pp. 31-42, (2017) (PubMed).
: "Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals." in: Nature communications, Vol. 7, pp. 10944, (2016) (PubMed).
: "Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture." in: Journal of virology, Vol. 89, Issue 20, pp. 10347-58, (2015) (PubMed).
: "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." in: Oncology reports, Vol. 34, Issue 5, pp. 2251-8, (2015) (PubMed).
: "Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation." in: The Journal of biological chemistry, Vol. 288, Issue 15, pp. 10703-14, (2013) (PubMed).
: "The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis." in: Science signaling, Vol. 5, Issue 228, pp. ra42, (2012) (PubMed).
: "VMD2 promoter requires two proximal E-box sites for its activity in vivo and is regulated by the MITF-TFE family." in: The Journal of biological chemistry, Vol. 282, Issue 3, pp. 1838-50, (2007) (PubMed).
Aliases for TFEB 抗体
transcription factor EB (TFEB) 抗体transcription factor EB (tfeb) 抗体
transcription factor EB (Tfeb) 抗体
alphatfeb 抗体
ALPHATFEB 抗体
BHLHE35 抗体
bHLHe35 抗体
MGC145796 抗体
tcfeb 抗体
TCFEB 抗体
Tcfeb 抗体
TFEB 抗体
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