TFE3 产品
(Transcription Factor E3 (TFE3))
Categories
The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1)\; it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.[provided by RefSeq, Dec 2009].
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Featured TFE3 Categories
TFE3 抗体
High quality antibodies with extensive validation data.
TFE3 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
TFE3 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TFE3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6257542
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN1683323
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN1538859
Quantity
400 μL
Datasheet
Datasheet
Recommended TFE3 ELISA试剂盒
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Reactivity
Analytical Method
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Cat. No.
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960060
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Qualitative DNA-Binding ELISA
Validations
Cat. No.
ABIN5648528
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5659395
Quantity
96 tests
Datasheet
Datasheet
Recommended TFE3 蛋白
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Reactivity
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Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125447
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322559
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
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Cat. No.
ABIN1322561
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our TFE3 Products
: "Hypoxia induces TFE3 expression in head and neck squamous cell carcinoma." in: Oncotarget, Vol. 7, Issue 10, pp. 11651-63, (2016) (PubMed).: "Resetting transcription factor control circuitry toward ground-state pluripotency in human." in: Cell, Vol. 158, Issue 6, pp. 1254-69, (2014) (PubMed).
: "Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3." in: Cell, Vol. 153, Issue 2, pp. 335-47, (2013) (PubMed).
: "Derivation of novel human ground state naive pluripotent stem cells. ..." in: Nature, Vol. 504, Issue 7479, pp. 282-6, (2013) (PubMed).
: "Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization." in: PLoS ONE, Vol. 5, Issue 12, pp. e15793, (2011) (PubMed).
: "Myc/Max and other helix-loop-helix/leucine zipper proteins bend DNA toward the minor groove." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 24, pp. 11779-83, (1993) (PubMed).
: "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation." in: Molecular and cellular biology, Vol. 13, Issue 8, pp. 4505-12, (1993) (PubMed).
: "TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif." in: Genes & development, Vol. 4, Issue 2, pp. 167-79, (1990) (PubMed).
: "A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins." in: Cell, Vol. 56, Issue 5, pp. 777-83, (1989) (PubMed).
Synonyms and alternative names related to TFE3
transcription factor binding to IGHM enhancer 3 (TFE3), transcription factor E3 (Tfe3), transcription factor binding to IGHM enhancer 3 (Tfe3), transcription factor binding to IGHM enhancer 3 S homeolog (tfe3.S), transcription factor binding to IGHM enhancer 3a (tfe3a), bHLHe33, cb873, F830016E06Rik, RCCP2, RCCX1, RGD1559642, Tcfe3, Tfe-3, TFEA, zgc:109815Protein level used designations for TFE3
- class E basic helix-loop-helix protein 33
- transcription factor E family, member A
- transcription factor E3
- transcription factor for IgH enhancer
- transcription factor for immunoglobulin heavy-chain enhancer 3
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