TET1 产品
(Tet Methylcytosine Dioxygenase 1 (TET1))
Categories
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.
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Featured TET1 Categories
Recommended TET1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN1327194
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (1)
Cat. No.
ABIN7159633
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB
Validations
- (1)
Cat. No.
ABIN6244141
Quantity
400 μL
Datasheet
Datasheet
Recommended TET1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322493
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells, Insect cells (Sf9)
Validations
Cat. No.
ABIN6700690
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our TET1 Products
: "Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs." in: Stem cells international, Vol. 2018, pp. 6013728, (2018) (PubMed).: "TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing." in: The EMBO journal, Vol. 35, Issue 3, pp. 335-55, (2016) (PubMed).
: "Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate." in: The Journal of biological chemistry, Vol. 291, Issue 13, pp. 6754-71, (2016) (PubMed).
: "Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells." in: Oncology letters, Vol. 10, Issue 3, pp. 1287-1292, (2015) (PubMed).
: "Restored expression levels of TET1 decrease the proliferation and migration of renal carcinoma cells." in: Molecular medicine reports, Vol. 12, Issue 4, pp. 4837-42, (2015) (PubMed).
: "Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT)." in: The Journal of biological chemistry, Vol. 290, Issue 8, pp. 4801-12, (2015) (PubMed).
: "TET1-mediated different transcriptional regulation in prostate cancer." in: International journal of clinical and experimental medicine, Vol. 8, Issue 1, pp. 203-11, (2015) (PubMed).
Synonyms and alternative names related to TET1
tet methylcytosine dioxygenase 1 (TET1), tet methylcytosine dioxygenase 1 (Tet1), solute carrier family 25 member 16 (SLC25A16), 2510010B09Rik, AA517754, bA119F7.1, BB001228, CXXC6, Cxxc6, D10Ertd17e, LCX, mKIAA1676Protein level used designations for TET1
- CXXC finger 6
- CXXC zinc finger 6
- CXXC-type zinc finger protein 6
- leukemia-associated protein with a CXXC domain
- methylcytosine dioxygenase TET1
- ten-eleven translocation 1 gene protein
- ten-eleven translocation-1
- tet oncogene 1
- ten-eleven translocation 1 gene protein homolog
- tet methylcytosine dioxygenase 1
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