TDG 产品
(Thymine-DNA Glycosylase (TDG))
Categories
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008].
antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.
Featured TDG Categories
TDG 抗体
High quality antibodies with extensive validation data.
TDG ELISA试剂盒
Reliable ELISA kits for a wide range of species.
TDG 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TDG 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7153379
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN520808
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (2)
Cat. No.
ABIN6258811
Quantity
100 μL
Datasheet
Datasheet
Recommended TDG ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959949
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1134027
Quantity
96 tests
Datasheet
Datasheet
Recommended TDG 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN1098673
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322426
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1785499
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our TDG Products
: "Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability." in: Genome biology, Vol. 19, Issue 1, pp. 37, (2018) (PubMed).: "A G-quadruplex-selective luminescent probe with an anchor tail for the switch-on detection of thymine DNA glycosylase activity." in: Biosensors & bioelectronics, Vol. 86, pp. 849-57, (2016) (PubMed).
: "TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1." in: Oncogene, Vol. 36, Issue 16, pp. 2202-2214, (2016) (PubMed).
: "Base excision repair of tandem modifications in a methylated CpG dinucleotide." in: The Journal of biological chemistry, Vol. 289, Issue 20, pp. 13996-4008, (2014) (PubMed).
: "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1." in: Nature, Vol. 435, Issue 7044, pp. 979-82, (2005) (PubMed).
: "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover." in: The EMBO journal, Vol. 21, Issue 6, pp. 1456-64, (2002) (PubMed).
: "Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12767-74, (1996) (PubMed).
: "Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1642-6, (1994) (PubMed).
Synonyms and alternative names related to TDG
thymine DNA glycosylase (TDG), thymine DNA glycosylase, tandem duplicate 1 (tdg.1), putative g/t mismatch-specific thymine DNA glycosylase (Smp_149220), G/T mismatch-specific thymine DNA glycosylase (Tsp_05734), thymine DNA glycosylase S homeolog (tdg.S), thymine DNA glycosylase (tdg), thymine DNA glycosylase (Tdg), thymine-DNA glycosylase (Tdg), 5-MCDG, E130317C12Rik, hTDG, JZA-3, Jza1, MGC82456, MGC89441, wu:fb44b11, zgc:110622Protein level used designations for TDG
- G/T mismatch-specific thymine DNA glycosylase
- G/T mismatch DNA glycosylase
- G/t mismatch-specific thymine DNA glycosylase
- thymine-DNA glycosylase
- G/T mismatch-specific thymine DNA glycosylase-like
- g/T mismatch-specific thymine DNA glycosylase-like
- C-JUN leucine zipper interactive protein JZA-3
You are here:
