TCF3 抗体
(Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\;19), with PBX1), childhood leukemia (t(19\;19), with TFPT) and acute leukemia (t(12\;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011].
recommended
recommended
TCF3 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB33747 unconjugated
recommended
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Datasheet
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Latest Publications for our TCF3 抗体
: "Sustained endoplasmic reticulum stress inhibits hepatocyte proliferation via downregulation of c-Met expression." in: Molecular and cellular biochemistry, Vol. 389, Issue 1-2, pp. 151-8, (2014) (PubMed).: "Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 29146-57, (2009) (PubMed).
: "Accelerated Notch-dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 6, pp. 3521-9, (2007) (PubMed).
: "Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 45028-35, (2004) (PubMed).
: "Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO." in: Developmental cell, Vol. 7, Issue 6, pp. 843-54, (2004) (PubMed).
: "Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities." in: The EMBO journal, Vol. 22, Issue 21, pp. 5780-92, (2003) (PubMed).
: "Inhibition of Tcf3 binding by I-mfa domain proteins." in: Molecular and cellular biology, Vol. 21, Issue 5, pp. 1866-73, (2001) (PubMed).
: "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function." in: The Journal of biological chemistry, Vol. 275, Issue 43, pp. 33567-73, (2000) (PubMed).
: "Both E12 and E47 allow commitment to the B cell lineage." in: Immunity, Vol. 6, Issue 2, pp. 145-54, (1997) (PubMed).
: "E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins." in: Molecular and cellular biology, Vol. 13, Issue 6, pp. 3522-9, (1993) (PubMed).
Aliases for TCF3 抗体
transcription factor 3 (TCF3) 抗体transcription factor 3b (tcf3b) 抗体
transcription factor 3 (Tcf3) 抗体
transcription factor 3 L homeolog (tcf3.L) 抗体
transcription factor E2a (tcfe2a) 抗体
A1 抗体
AA408400 抗体
ALF2 抗体
AW209082 抗体
bHLHb21 抗体
bhlhb21 抗体
E2A 抗体
e2a 抗体
E12 抗体
E12/E47 抗体
E47 抗体
G12 抗体
ITF1 抗体
itf1 抗体
ME2 抗体
Pan1 抗体
Pan2 抗体
TCF-3 抗体
tcf3a 抗体
TCF7L1 抗体
Tcfe2a 抗体
tcfe2a 抗体
VDIR 抗体
vdir 抗体
XE3 抗体
xtcf-3 抗体
xtcf3 抗体
zgc:113045 抗体
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