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This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008].
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T-Bet 抗体
High quality antibodies with extensive validation data.
T-Bet ELISA试剂盒
Reliable ELISA kits for a wide range of species.
T-Bet 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended T-Bet 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7442723
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN6265489
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Bat, Cow, Dog, Guinea Pig, Human, Monkey, Pig, Rabbit, Rat
Application
WB, IHC, IHC (p)
Validations
- (3)
Cat. No.
ABIN6735814
Quantity
100 μL
Datasheet
Datasheet
Recommended T-Bet ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970533
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970532
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959837
Quantity
96 tests
Datasheet
Datasheet
Recommended T-Bet 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322292
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1322294
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125305
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our T-Bet Products
: "Glycogen synthase kinase‑3β inhibitor reduces LPS‑induced acute lung injury in mice." in: Molecular medicine reports, Vol. 16, Issue 5, pp. 6715-6721, (2018) (PubMed).: "Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 196, Issue 9, pp. 3706-15, (2016) (PubMed).
: "Bacillus subtilis KCTC 11782BP-Produced Alginate Oligosaccharide Effectively Suppresses Asthma via T-Helper Cell Type 2-Related Cytokines." in: PLoS ONE, Vol. 10, Issue 2, pp. e0117524, (2015) (PubMed).
: "S100A9: A Potential Biomarker for the Progression of Non-Alcoholic Fatty Liver Disease and the Diagnosis of Non-Alcoholic Steatohepatitis." in: PLoS ONE, Vol. 10, Issue 5, pp. e0127352, (2015) (PubMed).
: "The effect of adalimumab on key drivers in the pathogenesis of psoriasis." in: The British journal of dermatology, Vol. 170, Issue 3, pp. 571-80, (2014) (PubMed).
: "T-Bet Mediated Anti-Neoplastic Effects of Dendritic Cell-Cytokine Induced Killer Cells in vitro." in: Iranian journal of pediatrics, Vol. 22, Issue 1, pp. 43-51, (2012) (PubMed).
: "IL-36γ/IL-1F9, an innate T-bet target in myeloid cells." in: The Journal of biological chemistry, Vol. 287, Issue 50, pp. 41684-96, (2012) (PubMed).
: "TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 5, pp. 2278-90, (2011) (PubMed).
: "Regional immunity in melanoma: immunosuppressive changes precede nodal metastasis." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 24, Issue 4, pp. 487-94, (2011) (PubMed).
: "The T-box transcription factor T-bet in immunity and autoimmunity." in: Cellular & molecular immunology, Vol. 3, Issue 2, pp. 87-95, (2006) (PubMed).
Synonyms and alternative names related to T-Bet
T-box 21 (TBX21), T-box 21 (Tbx21), T-bet, T-PET, TBET, Tbet, TBLYM, Tblym, TBT1Protein level used designations for T-Bet
- T-box expressed in T cells
- T-box protein 21
- T-box transcription factor TBX21
- T-cell-specific T-box transcription factor T-bet
- transcription factor TBLYM
- t-box transcription factor TBX21
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