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TAF1 产品

(TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1))
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.[provided by RefSeq, Aug 2009].

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Featured TAF1 Categories

TAF1 抗体

High quality antibodies with extensive validation data.

TAF1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

TAF1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TAF1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (4)
Cat. No. ABIN233826
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
Application WB, IHC, ChIP
Validations
  • (4)
Cat. No. ABIN2779667
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN563083
Quantity 100 μg
Datasheet Datasheet

Recommended TAF1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1162526
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5594421
Quantity 96 tests
Datasheet Datasheet

Recommended TAF1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125310
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125311
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125309
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our TAF1 Products

Gegonne, Tai, Zhang, Wu, Zhu, Yoshimoto, Hanson, Cultraro, Chen, Guinter, Yang, Hathcock, Singer, Rodriguez-Canales, Tessarollo, Mackem, Meerzaman, Buetow, Singer: "The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells." in: Molecular and cellular biology, Vol. 32, Issue 10, pp. 1984-97, (2012) (PubMed).

Li, Li, Sheppard, Liu: "Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression." in: Molecular cell, Vol. 13, Issue 6, pp. 867-78, (2004) (PubMed).

Solow, Salunek, Ryan, Lieberman: "Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 15886-92, (2001) (PubMed).

Jacobson, Ladurner, King, Tjian: "Structure and function of a human TAFII250 double bromodomain module." in: Science (New York, N.Y.), Vol. 288, Issue 5470, pp. 1422-5, (2000) (PubMed).

Synonyms and alternative names related to TAF1

TBP-associated factor 1 (Taf1), TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa (TAF1), transcription initiation factor TFIID subunit 1 (LOC5567420), transcription initiation factor TFIID subunit 1 (CpipJ_CPIJ003658), transcription initiation factor TFIID subunit 1 (TAF11.1), transcription initiation factor TFIID, subunit TAF1 (HAF1501), transcription initiation factor TFIID, subunit TAF1 (HAF1502), TATA-box binding protein associated factor 1 (TAF1), transcription initiation factor TFIID subunit 1 (LOC100457071), TATA-box binding protein associated factor 1 (Taf1), 250kDa, AU015687, B430306D02Rik, BA2R, BG:DS00004.13, Ccg-1, Ccg1, CCG1, CCGS, cel, cell, CG17603, d230, Dmel\\CG17603, dmTAF1, dmTAF[[II]]230, dTAF230, dTAF250, dTAFII250, dTAF[[II]]230, dTAF[[II]]250, DYT3, DYT3/TAF1, EfW1, KAT4, l(3)84Ab, N-TAF1, NSCL2, OF, p230, P250, p250, RGD1562050, SR3-5, TAF, TAF(II)250, TAF1, Taf1p, Taf2a, TAF2A, TAF200, Taf200, TAF230, Taf230, TAF250, Taf250, TAF250/230, TAFII-250, TAFII250, TAF[II]250, TAF[[II]], TAF[[II]]230, TAF[[II]]250, Taf[[II]]250, TAF[[II]]250/230, TFIID, TFIID TAF250, XDP

Protein level used designations for TAF1

  • CG17603-PA
  • CG17603-PB
  • CG17603-PC
  • CG17603-PD
  • CG17603-PE
  • TATA-associated factor 250
  • TBP-associated factor
  • TBP-associated factor 250
  • TBP-associated factor 250kD
  • TFIID 230 kda subunit
  • Taf1-PA
  • Taf1-PB
  • Taf1-PC
  • Taf1-PD
  • Taf1-PE
  • cell lethal
  • suppressor of Ras85D 3-5
  • TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
  • transcription initiation factor TFIID subunit 1
  • transcription initiation factor TFIID, subunit TAF1
  • TBP-associated factor 1-like
  • transcription initiation factor TFIID subunit 1-like
  • TAF(II)250
  • TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, neuron specific isoform
  • TAFII-250
  • TBP-associated factor 250 kDa
  • cell cycle gene 1 protein
  • cell cycle, G1 phase defect
  • p250
  • transcription initiation factor TFIID 250 kDa subunit
  • complementation of cell cycle block, G1-to-S
  • transcription factor TFIID p250 polypeptide
  • Cell cycle gene 1 protein
  • Transcription initiation factor TFIID 250 kDa subunit
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