SUMO4 产品
(Small Ubiquitin Related Modifier 4 (SUMO4))
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This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008].
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Latest Publications for our SUMO4 Products
: "Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2." in: The EMBO journal, Vol. 27, Issue 2, pp. 350-60, (2008) (PubMed).: "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes." in: Nature genetics, Vol. 37, Issue 2, pp. 112; author reply 112-3, (2005) (PubMed).
: "A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus." in: The Journal of biological chemistry, Vol. 279, Issue 26, pp. 27233-8, (2004) (PubMed).
: "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. ..." in: Nature genetics, Vol. 36, Issue 8, pp. 837-41, (2004) (PubMed).
Synonyms and alternative names related to SUMO4
small ubiquitin-like modifier 4 (SUMO4), small ubiquitin-related modifier 4 (sumo4), SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) (SUMO4), dJ281H8.4, IDDM5, SMT3H4, SUMO-4Protein level used designations for SUMO4
- SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
- small ubiquitin-related modifier 4
- SMT3 suppressor of mif two 3 homolog 2
- SMT3 suppressor of mif two 3 homolog 4
- small ubiquitin-like modifier 4 protein
- SUMO-4
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