STRADA 产品
(STE20-Related Kinase Adaptor alpha (STRADA))
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The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009].
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Recommended STRADA 抗体
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Cat. No.
ABIN1981302
Quantity
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Datasheet
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Cat. No.
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Quantity
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Reactivity
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Application
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Quantity
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Datasheet
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Recommended STRADA 蛋白
Latest Publications for our STRADA Products
: "GSK-3? controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells." in: The Prostate, (2015) (PubMed).: "Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase." in: Obesity research & clinical practice, Vol. 4, Issue 3, pp. e163-246, (2013) (PubMed).
: "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression." in: Cancer immunity, Vol. 1, pp. 4, (2003) (PubMed).
: "Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD." in: The EMBO journal, Vol. 22, Issue 12, pp. 3062-72, (2003) (PubMed).
Synonyms and alternative names related to STRADA
STE20-related kinase adaptor alpha (STRADA), ste20-related kinase adaptor alpha (strada), STE20-related kinase adaptor alpha (strada), STE20-related kinase adaptor alpha (Strada), 2610019A05Rik, 6030402H20Rik, AI480680, E130112C09Rik, fj99g05, lyk5, LYK5, Lyk5, NY-BR-96, PMSE, Stlk, STRAD, wu:fj99g05, zgc:56109Protein level used designations for STRADA
- protein kinase LYK5
- STE20-related kinase adapter protein alpha
- STE20-related kinase adaptor alpha
- STE20-related kinase adapter protein alpha-like
- STE20-like pseudokinase
- STRAD alpha
- serologically defined breast cancer antigen NY-BR-96
- STE20-related adapter protein
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