STING/TMEM173 产品
(Transmembrane Protein 173 (TMEM173))
Categories
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
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Featured STING/TMEM173 Categories
STING/TMEM173 抗体
High quality antibodies with extensive validation data.
STING/TMEM173 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
STING/TMEM173 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended STING/TMEM173 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7439447
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, IF
Validations
- (8)
Cat. No.
ABIN6220283
Quantity
20 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p)
Validations
- (9)
Cat. No.
ABIN1501428
Quantity
100 μL
Datasheet
Datasheet
Recommended STING/TMEM173 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970832
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960146
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6999504
Quantity
96 tests
Datasheet
Datasheet
Recommended STING/TMEM173 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125482
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7092708
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7319452
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our STING/TMEM173 Products
: "The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway." in: PLoS pathogens, Vol. 14, Issue 11, pp. e1007435, (2019) (PubMed).: "The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus." in: Cell reports, Vol. 26, Issue 9, pp. 2377-2393.e13, (2019) (PubMed).
: "STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade." in: The Journal of clinical investigation, Vol. 130, pp. 4350-4364, (2019) (PubMed).
: "Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents." in: Oncotarget, Vol. 7, Issue 47, pp. 77205-77224, (2018) (PubMed).
: "Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses." in: Nature communications, Vol. 9, Issue 1, pp. 125, (2018) (PubMed).
: "HPV18 Persistence Impairs Basal and DNA Ligand-Mediated IFN-β and IFN-λ1 Production through Transcriptional Repression of Multiple Downstream Effectors of Pattern Recognition Receptor Signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 6, pp. 2076-2089, (2018) (PubMed).
: "PARP1 depletion induces RIG-I-dependent signaling in human cancer cells." in: PLoS ONE, Vol. 13, Issue 3, pp. e0194611, (2018) (PubMed).
: "UBXN3B positively regulates STING-mediated antiviral immune responses." in: Nature communications, Vol. 9, Issue 1, pp. 2329, (2018) (PubMed).
: "RAD51 interconnects between DNA replication, DNA repair and immunity." in: Nucleic acids research, Vol. 45, Issue 8, pp. 4590-4605, (2017) (PubMed).
: "Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway." in: Nature structural & molecular biology, Vol. 24, Issue 12, pp. 1124-1131, (2017) (PubMed).
Synonyms and alternative names related to STING/TMEM173
transmembrane protein 173 (TMEM173), transmembrane protein 173 (Tmem173), 2610307O08Rik, ERIS, MITA, Mita, MPYS, NET23, RGD1562552, STINGProtein level used designations for STING/TMEM173
- transmembrane protein 173
- N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
- STING1
- endoplasmic reticulum IFN stimulator
- endoplasmic reticulum interferon stimulator
- hMITA
- hSTING
- mediator of IRF3 activation
- mitochondrial mediator of IRF3 activation
- stimulator of interferon genes protein
- MMITA
- mSTING
- Stimulator of interferon genes protein
- mitochondrial transmembrane protein 173
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