STIM1 产品
(Stromal Interaction Molecule 1 (STIM1))
Categories
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.[provided by RefSeq, Jan 2009].
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Featured STIM1 Categories
STIM1 抗体
High quality antibodies with extensive validation data.
STIM1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
STIM1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended STIM1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (20)
- (5)
Cat. No.
ABIN563045
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7444409
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IP, IHC (p), ICC
Validations
- (2)
- (3)
Cat. No.
ABIN192394
Quantity
0.1 mg
Datasheet
Datasheet
Recommended STIM1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730286
Quantity
96 tests
Datasheet
Datasheet
Recommended STIM1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1321631
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN666653
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7418308
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our STIM1 Products
: "Suppression of STIM1 inhibits the migration and invasion of human prostate cancer cells and is associated with PI3K/Akt signaling inactivation." in: Oncology reports, Vol. 38, Issue 5, pp. 2629-2636, (2018) (PubMed).: "A Novel Strategy for TNF-Alpha Production by 2-APB Induced Downregulated SOCE and Upregulated HSP70 in O. tsutsugamushi-Infected Human Macrophages." in: PLoS ONE, Vol. 11, Issue 7, pp. e0159299, (2017) (PubMed).
: "Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 146, Issue 1, pp. 116-26, (2015) (PubMed).
: "IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: A plausible mechanism of IL-9R in atopic dermatitis." in: Journal of dermatological science, Vol. 78, Issue 3, pp. 206-14, (2015) (PubMed).
: "STIM1 and SLC24A4 Are Critical for Enamel Maturation." in: Journal of dental research, Vol. 93, Issue 7 Suppl, pp. 94S-100S, (2015) (PubMed).
: "STIM1 and STIM2 proteins differently regulate endogenous store-operated channels in HEK293 cells." in: The Journal of biological chemistry, Vol. 290, Issue 8, pp. 4717-27, (2015) (PubMed).
: "Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation." in: Immunity, inflammation and disease, Vol. 3, Issue 3, pp. 154-70, (2015) (PubMed).
: "Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding." in: PLoS ONE, Vol. 10, Issue 6, pp. e0128622, (2015) (PubMed).
: "Inside-out Ca(2+) signalling prompted by STIM1 conformational switch." in: Nature communications, Vol. 6, pp. 7826, (2015) (PubMed).
: "Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression." in: Cell reports, Vol. 12, Issue 2, pp. 203-16, (2015) (PubMed).
Synonyms and alternative names related to STIM1
stromal interaction molecule 1 (STIM1), stromal interaction molecule 1 (stim1), stromal interaction molecule 1a (stim1a), stromal interaction molecule 1 L homeolog (stim1.L), stromal interaction molecule 1b (stim1b), stromal interaction molecule 1 (Stim1), D11S4896E, GOK, MGC76045, MGC154748, si:ch211-112l17.2, si:dkey-24p1.5, SIM, stim1, STIM1, Stim1, TAMProtein level used designations for STIM1
- stromal interaction molecule 1
- stromal interaction molecule 1b
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