STAT6 产品
(Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
Categories
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
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Featured STAT6 Categories
STAT6 抗体
High quality antibodies with extensive validation data.
STAT6 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
STAT6 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended STAT6 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (6)
Cat. No.
ABIN563038
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IP, ICC, IF
Validations
- (5)
Cat. No.
ABIN6255720
Quantity
100 μL
Datasheet
Datasheet
Application
WB, IHC, IHC (p)
Validations
- (5)
Cat. No.
ABIN6745701
Quantity
100 μL
Datasheet
Datasheet
Recommended STAT6 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Semi-Quantitative Cell ELISA
Validations
- (1)
- (5)
Cat. No.
ABIN1981845
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
Cat. No.
ABIN1981731
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
Cat. No.
ABIN4889794
Quantity
96 tests
Datasheet
Datasheet
Recommended STAT6 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125097
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125096
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321610
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our STAT6 Products
: "Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Leishmania major." in: Frontiers in immunology, Vol. 9, pp. 1, (2019) (PubMed).: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).
: "Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice." in: The Journal of experimental medicine, Vol. 215, Issue 8, pp. 2175-2195, (2018) (PubMed).
: "Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D2 Receptor Subtype 1." in: The Journal of pharmacology and experimental therapeutics, Vol. 360, Issue 3, pp. 435-444, (2017) (PubMed).
: "Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 99, pp. 60-69, (2017) (PubMed).
: "The effect of the TLR9 ligand CpG-oligodeoxynucleotide on the protective immune response to radiation-induced lung fibrosis in mice." in: Molecular immunology, Vol. 80, pp. 33-40, (2017) (PubMed).
: "Radiation-induced lung fibrosis in a tumor-bearing mouse model is associated with enhanced Type-2 immunity." in: Journal of radiation research, Vol. 57, Issue 2, pp. 133-41, (2017) (PubMed).
: "IL-4 Downregulates IL-1β and IL-6 and Induces GATA3 in Psoriatic Epidermal Cells: Route of Action of a Th2 Cytokine." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 4, pp. 1744-52, (2015) (PubMed).
: "STATs profiling reveals predominantly-activated STAT3 in cholangiocarcinoma genesis and progression." in: Journal of hepato-biliary-pancreatic sciences, Vol. 21, Issue 10, pp. 767-76, (2014) (PubMed).
: "The role of STAT-6 as a key transcription regulator in HeLa cell death induced by IFN-?/TNF-? co-immobilized on nanoparticles." in: Biomaterials, Vol. 35, Issue 18, pp. 5016-27, (2014) (PubMed).
Synonyms and alternative names related to STAT6
signal transducer and activator of transcription 6 (STAT6), signal transducer and activator of transcription 6 (Stat6), signal transducer and activator of transcription 6-like (LOC100859543), D12S1644, IL-4-STAT, STAT6B, STAT6CProtein level used designations for STAT6
- signal transducer and transcription activator 6
- STAT, interleukin4-induced
- signal transducer and activator of transcription 6
- transcription factor IL-4 STAT
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